Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism

Mauro AM Carai1, Noemi Fantini1, Barbara Loi1, Giancarlo Colombo1, Antonella Riva2, Paolo Morazzoni21C.N.R. Institute of Neuroscience, Cagliari, Italy; 2Indena SpA, Milan, ItalyAbstract: Preclinical data on extracts of and preparations derived from beans of Phaseolus vulgaris are reviewed as potenti...

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Autores principales:	Mauro AM Carai, Noemi Fantini, Barbara Loi, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/b974d81b34a44189bba66b82ed176be8
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spelling	oai:doaj.org-article:b974d81b34a44189bba66b82ed176be82021-12-02T09:23:25ZPotential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism1178-7007https://doaj.org/article/b974d81b34a44189bba66b82ed176be82009-09-01T00:00:00Zhttp://www.dovepress.com/potential-efficacy-of-preparations-derived-from-phaseolus-vulgaris-in--a3515https://doaj.org/toc/1178-7007Mauro AM Carai1, Noemi Fantini1, Barbara Loi1, Giancarlo Colombo1, Antonella Riva2, Paolo Morazzoni21C.N.R. Institute of Neuroscience, Cagliari, Italy; 2Indena SpA, Milan, ItalyAbstract: Preclinical data on extracts of and preparations derived from beans of Phaseolus vulgaris are reviewed as potential remedies for use in controlling food consumption, body weight, lipid accumulation, and glycemia. A growing body of evidence suggests that acute and chronic administration of P. vulgaris derivatives reduces food intake (including highly palatable foods), body weight, lipid deposit, and glycemia in rats exposed to multiple experimental procedures. Two possible lectin-mediated mechanisms of action have been proposed: (a) inhibition of &alpha;-amylase, resulting in a reduced carbohydrate metabolism and absorption; (b) phytohemoagglutinininduced modulation of the activity of cholecystokinin and glucagon-like peptides, resulting in a reduced appetite. Preliminary clinical data, as well as reports focusing on the use of several traditional medicines, apparently extend these findings to humans. Should these initial clinical data be confirmed by future surveys, P. vulgaris derivatives might constitute novel remedies for the treatment of obesity and metabolic syndrome. Future studies are also expected to identify active structures leading to the development of new pharmaceutical agents.Keywords: Phaseolus vulgaris extracts and derivatives, food intake, body weight, lipid accumulation, glycemia, obesity, diabetes, metabolic syndrome Mauro AM CaraiNoemi FantiniBarbara Loiet alDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2009, Iss default, Pp 145-153 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Mauro AM Carai Noemi Fantini Barbara Loi et al Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
description	Mauro AM Carai1, Noemi Fantini1, Barbara Loi1, Giancarlo Colombo1, Antonella Riva2, Paolo Morazzoni21C.N.R. Institute of Neuroscience, Cagliari, Italy; 2Indena SpA, Milan, ItalyAbstract: Preclinical data on extracts of and preparations derived from beans of Phaseolus vulgaris are reviewed as potential remedies for use in controlling food consumption, body weight, lipid accumulation, and glycemia. A growing body of evidence suggests that acute and chronic administration of P. vulgaris derivatives reduces food intake (including highly palatable foods), body weight, lipid deposit, and glycemia in rats exposed to multiple experimental procedures. Two possible lectin-mediated mechanisms of action have been proposed: (a) inhibition of &alpha;-amylase, resulting in a reduced carbohydrate metabolism and absorption; (b) phytohemoagglutinininduced modulation of the activity of cholecystokinin and glucagon-like peptides, resulting in a reduced appetite. Preliminary clinical data, as well as reports focusing on the use of several traditional medicines, apparently extend these findings to humans. Should these initial clinical data be confirmed by future surveys, P. vulgaris derivatives might constitute novel remedies for the treatment of obesity and metabolic syndrome. Future studies are also expected to identify active structures leading to the development of new pharmaceutical agents.Keywords: Phaseolus vulgaris extracts and derivatives, food intake, body weight, lipid accumulation, glycemia, obesity, diabetes, metabolic syndrome
format	article
author	Mauro AM Carai Noemi Fantini Barbara Loi et al
author_facet	Mauro AM Carai Noemi Fantini Barbara Loi et al
author_sort	Mauro AM Carai
title	Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
title_short	Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
title_full	Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
title_fullStr	Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
title_full_unstemmed	Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
title_sort	potential efficacy of preparations derived from phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/b974d81b34a44189bba66b82ed176be8
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Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism

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