MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS

Abstract.The effect of a hexamer fragment of the peptide differentiation factor of the HL–60 cell line, HLDF6, on functional activity of C57Bl/6 mouse macrophages upon adding selective agonists of μ–, δ– and κ–type opiate receptors (DAGO, DADLE and Dynorphin (1–13) has been studied in the cell cultu...

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Autores principales:	E. D. Danilenko, V. A. Fadina, V. I. Мasycheva, V. V. Samukov, I. A. Коstanyan
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hldf6 peptide opiate agonists macrophages Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b975591d759148a7a33879b16f1063a8
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spelling	oai:doaj.org-article:b975591d759148a7a33879b16f1063a82021-11-18T08:03:41ZMODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS1563-06252313-741X10.15789/1563-0625-2005-1-77-84https://doaj.org/article/b975591d759148a7a33879b16f1063a82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/434https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract.The effect of a hexamer fragment of the peptide differentiation factor of the HL–60 cell line, HLDF6, on functional activity of C57Bl/6 mouse macrophages upon adding selective agonists of μ–, δ– and κ–type opiate receptors (DAGO, DADLE and Dynorphin (1–13) has been studied in the cell culture. It has been shown that opiate agonists were capable of enhancing adhesive properties and functional activity of macrophages during their direct interaction with cells. The intensity of stimulation depended on the type of the agonist and, respectively, the type of the opiate receptor. HLDF6 peptide enhanced macrophage activity after addition to the culture medium both at the initial cultivation stage and at the moment of phagosytosis induction. The data concerning the combined administration of HLDF6 and opiate agonists suggest the interaction between the peptide and the endogenous opiate system. (Med. Immunol., 2005, vol.7, № 1, pp 77584)E. D. DanilenkoV. A. FadinaV. I. МasychevaV. V. SamukovI. A. КоstanyanSPb RAACIarticlehldf6 peptideopiate agonistsmacrophagesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 1, Pp 77-84 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hldf6 peptide opiate agonists macrophages Immunologic diseases. Allergy RC581-607
spellingShingle	hldf6 peptide opiate agonists macrophages Immunologic diseases. Allergy RC581-607 E. D. Danilenko V. A. Fadina V. I. Мasycheva V. V. Samukov I. A. Коstanyan MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
description	Abstract.The effect of a hexamer fragment of the peptide differentiation factor of the HL–60 cell line, HLDF6, on functional activity of C57Bl/6 mouse macrophages upon adding selective agonists of μ–, δ– and κ–type opiate receptors (DAGO, DADLE and Dynorphin (1–13) has been studied in the cell culture. It has been shown that opiate agonists were capable of enhancing adhesive properties and functional activity of macrophages during their direct interaction with cells. The intensity of stimulation depended on the type of the agonist and, respectively, the type of the opiate receptor. HLDF6 peptide enhanced macrophage activity after addition to the culture medium both at the initial cultivation stage and at the moment of phagosytosis induction. The data concerning the combined administration of HLDF6 and opiate agonists suggest the interaction between the peptide and the endogenous opiate system. (Med. Immunol., 2005, vol.7, № 1, pp 77584)
format	article
author	E. D. Danilenko V. A. Fadina V. I. Мasycheva V. V. Samukov I. A. Коstanyan
author_facet	E. D. Danilenko V. A. Fadina V. I. Мasycheva V. V. Samukov I. A. Коstanyan
author_sort	E. D. Danilenko
title	MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
title_short	MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
title_full	MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
title_fullStr	MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
title_full_unstemmed	MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS
title_sort	modulation of functional macrophage activity by hldf6 peptide upon adding opiate receptor agonists
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b975591d759148a7a33879b16f1063a8
work_keys_str_mv	AT eddanilenko modulationoffunctionalmacrophageactivitybyhldf6peptideuponaddingopiatereceptoragonists AT vafadina modulationoffunctionalmacrophageactivitybyhldf6peptideuponaddingopiatereceptoragonists AT vimasycheva modulationoffunctionalmacrophageactivitybyhldf6peptideuponaddingopiatereceptoragonists AT vvsamukov modulationoffunctionalmacrophageactivitybyhldf6peptideuponaddingopiatereceptoragonists AT iakostanyan modulationoffunctionalmacrophageactivitybyhldf6peptideuponaddingopiatereceptoragonists
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MODULATION OF FUNCTIONAL MACROPHAGE ACTIVITY BY HLDF6 PEPTIDE UPON ADDING OPIATE RECEPTOR AGONISTS

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