Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites

Abstract With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J w...

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Autores principales:	Ariane Zamarioli, Zachery R. Campbell, Kevin A. Maupin, Paul J. Childress, Joao P. B. Ximenez, Gremah Adam, Nabarun Chakraborty, Aarti Gautam, Rasha Hammamieh, Melissa A. Kacena
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/b975b97ec90645fda468f236688c4df4
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spelling	oai:doaj.org-article:b975b97ec90645fda468f236688c4df42021-12-02T16:36:00ZAnalysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites10.1038/s41526-021-00140-02373-8065https://doaj.org/article/b975b97ec90645fda468f236688c4df42021-03-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00140-0https://doaj.org/toc/2373-8065Abstract With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space (“Flight”) and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.Ariane ZamarioliZachery R. CampbellKevin A. MaupinPaul J. ChildressJoao P. B. XimenezGremah AdamNabarun ChakrabortyAarti GautamRasha HammamiehMelissa A. KacenaNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Ariane Zamarioli Zachery R. Campbell Kevin A. Maupin Paul J. Childress Joao P. B. Ximenez Gremah Adam Nabarun Chakraborty Aarti Gautam Rasha Hammamieh Melissa A. Kacena Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
description	Abstract With increased human presence in space, bone loss and fractures will occur. Thrombopoietin (TPO) is a recently patented bone healing agent. Here, we investigated the systemic effects of TPO on mice subjected to spaceflight and sustaining a bone fracture. Forty, 9-week-old, male, C57BL/6 J were divided into 4 groups: (1) Saline+Earth; (2) TPO + Earth; (3) Saline+Flight; and (4) TPO + Flight (n = 10/group). Saline- and TPO-treated mice underwent a femoral defect surgery, and 20 mice were housed in space (“Flight”) and 20 mice on Earth for approximately 4 weeks. With the exception of the calvarium and incisor, positive changes were observed in TPO-treated, spaceflight bones, suggesting TPO may improve osteogenesis in the absence of mechanical loading. Thus, TPO, may serve as a new bone healing agent, and may also improve some skeletal properties of astronauts, which might be extrapolated for patients on Earth with restraint mobilization and/or are incapable of bearing weight on their bones.
format	article
author	Ariane Zamarioli Zachery R. Campbell Kevin A. Maupin Paul J. Childress Joao P. B. Ximenez Gremah Adam Nabarun Chakraborty Aarti Gautam Rasha Hammamieh Melissa A. Kacena
author_facet	Ariane Zamarioli Zachery R. Campbell Kevin A. Maupin Paul J. Childress Joao P. B. Ximenez Gremah Adam Nabarun Chakraborty Aarti Gautam Rasha Hammamieh Melissa A. Kacena
author_sort	Ariane Zamarioli
title	Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
title_short	Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
title_full	Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
title_fullStr	Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
title_full_unstemmed	Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
title_sort	analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b975b97ec90645fda468f236688c4df4
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Analysis of the effects of spaceflight and local administration of thrombopoietin to a femoral defect injury on distal skeletal sites

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