A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle

Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression. An international team lead by Matteo Barberis from University of Amsterdam in The Netherlands studi...

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Autores principales:	Christian Linke, Anastasia Chasapi, Alberto González-Novo, Istabrak Al Sawad, Silvia Tognetti, Edda Klipp, Mart Loog, Sylvia Krobitsch, Francesc Posas, Ioannis Xenarios, Matteo Barberis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b97661edfbb74ad691b7c34f9005b5f8
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spelling	oai:doaj.org-article:b97661edfbb74ad691b7c34f9005b5f82021-12-02T16:08:59ZA Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle10.1038/s41540-017-0008-12056-7189https://doaj.org/article/b97661edfbb74ad691b7c34f9005b5f82017-03-01T00:00:00Zhttps://doi.org/10.1038/s41540-017-0008-1https://doaj.org/toc/2056-7189Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression. An international team lead by Matteo Barberis from University of Amsterdam in The Netherlands studied the molecular mechanisms responsible for the coordination of DNA replication with cell division. The researchers have demonstrated how the sequential order of waves of mitotic cyclins activating cyclin-dependent kinase, or Cdk, is achieved by synchronizing Cdk with transcriptional activities. They have generated a mathematical model that predicts a cyclin/Cdk-mediated regulation of an activator molecule to stimulate mitotic cyclin expression. This prediction was successfully validated experimentally, identifying Forkhead transcription factors, or Fkh, as pivotal molecules. Cyclin waves are temporally synchronized by Fkh, and a mitotic Clb/Cdk1-mediated regulation of Fkh modulates cyclin expression. The findings reveal a novel principle of design, with kinase and transcription activities interlocked to guarantee a timely cell cycle.Christian LinkeAnastasia ChasapiAlberto González-NovoIstabrak Al SawadSilvia TognettiEdda KlippMart LoogSylvia KrobitschFrancesc PosasIoannis XenariosMatteo BarberisNature PortfolioarticleBiology (General)QH301-705.5ENnpj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Christian Linke Anastasia Chasapi Alberto González-Novo Istabrak Al Sawad Silvia Tognetti Edda Klipp Mart Loog Sylvia Krobitsch Francesc Posas Ioannis Xenarios Matteo Barberis A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
description	Cell cycle control: Order in time achieved by dynamic coupling A dynamic coupling of cyclin-dependent kinase with transcription factors in yeast offers insights into the timely cell cycle progression. An international team lead by Matteo Barberis from University of Amsterdam in The Netherlands studied the molecular mechanisms responsible for the coordination of DNA replication with cell division. The researchers have demonstrated how the sequential order of waves of mitotic cyclins activating cyclin-dependent kinase, or Cdk, is achieved by synchronizing Cdk with transcriptional activities. They have generated a mathematical model that predicts a cyclin/Cdk-mediated regulation of an activator molecule to stimulate mitotic cyclin expression. This prediction was successfully validated experimentally, identifying Forkhead transcription factors, or Fkh, as pivotal molecules. Cyclin waves are temporally synchronized by Fkh, and a mitotic Clb/Cdk1-mediated regulation of Fkh modulates cyclin expression. The findings reveal a novel principle of design, with kinase and transcription activities interlocked to guarantee a timely cell cycle.
format	article
author	Christian Linke Anastasia Chasapi Alberto González-Novo Istabrak Al Sawad Silvia Tognetti Edda Klipp Mart Loog Sylvia Krobitsch Francesc Posas Ioannis Xenarios Matteo Barberis
author_facet	Christian Linke Anastasia Chasapi Alberto González-Novo Istabrak Al Sawad Silvia Tognetti Edda Klipp Mart Loog Sylvia Krobitsch Francesc Posas Ioannis Xenarios Matteo Barberis
author_sort	Christian Linke
title	A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
title_short	A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
title_full	A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
title_fullStr	A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
title_full_unstemmed	A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle
title_sort	clb/cdk1-mediated regulation of fkh2 synchronizes clb expression in the budding yeast cell cycle
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b97661edfbb74ad691b7c34f9005b5f8
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A Clb/Cdk1-mediated regulation of Fkh2 synchronizes CLB expression in the budding yeast cell cycle

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