Curcumin activates Nrf2 through PKCδ-mediated p62 phosphorylation at Ser351

Abstract Curcumin, a phytochemical extracted from Curcuma longa rhizomes, is known to be protective in neurons via activation of Nrf2, a master regulator of endogenous defense against oxidative stress in cells. However, the exact mechanism by which curcumin activates Nrf2 remains controversial. Here...

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Bibliographic Details
Main Authors: Jee-Yun Park, Hee-Young Sohn, Young Ho Koh, Chulman Jo
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
R
Q
Online Access:https://doaj.org/article/b97934da2cec41ec9c87cd0077eb6ec0
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