Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific interactions are known. Using TIRF microscopy based assays, functional studies and an experimentally validated prediction algorithm, the authors show that specific PIP binding is widespread among hum...

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Autores principales:	Nilmani Singh, Adriana Reyes-Ordoñez, Michael A. Compagnone, Jesus F. Moreno, Benjamin J. Leslie, Taekjip Ha, Jie Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b97a6563b3fc4a5b933ad000dc6e31ec
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spelling	oai:doaj.org-article:b97a6563b3fc4a5b933ad000dc6e31ec2021-12-02T15:33:16ZRedefining the specificity of phosphoinositide-binding by human PH domain-containing proteins10.1038/s41467-021-24639-y2041-1723https://doaj.org/article/b97a6563b3fc4a5b933ad000dc6e31ec2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24639-yhttps://doaj.org/toc/2041-1723Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific interactions are known. Using TIRF microscopy based assays, functional studies and an experimentally validated prediction algorithm, the authors show that specific PIP binding is widespread among human PH domains.Nilmani SinghAdriana Reyes-OrdoñezMichael A. CompagnoneJesus F. MorenoBenjamin J. LeslieTaekjip HaJie ChenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nilmani Singh Adriana Reyes-Ordoñez Michael A. Compagnone Jesus F. Moreno Benjamin J. Leslie Taekjip Ha Jie Chen Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
description	Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific interactions are known. Using TIRF microscopy based assays, functional studies and an experimentally validated prediction algorithm, the authors show that specific PIP binding is widespread among human PH domains.
format	article
author	Nilmani Singh Adriana Reyes-Ordoñez Michael A. Compagnone Jesus F. Moreno Benjamin J. Leslie Taekjip Ha Jie Chen
author_facet	Nilmani Singh Adriana Reyes-Ordoñez Michael A. Compagnone Jesus F. Moreno Benjamin J. Leslie Taekjip Ha Jie Chen
author_sort	Nilmani Singh
title	Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
title_short	Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
title_full	Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
title_fullStr	Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
title_full_unstemmed	Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins
title_sort	redefining the specificity of phosphoinositide-binding by human ph domain-containing proteins
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b97a6563b3fc4a5b933ad000dc6e31ec
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Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

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