Redefining the specificity of phosphoinositide-binding by human PH domain-containing proteins

Pleckstrin homology (PH) domains are presumed to bind phosphoinositides (PIPs) but only few specific interactions are known. Using TIRF microscopy based assays, functional studies and an experimentally validated prediction algorithm, the authors show that specific PIP binding is widespread among hum...

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Autores principales: Nilmani Singh, Adriana Reyes-Ordoñez, Michael A. Compagnone, Jesus F. Moreno, Benjamin J. Leslie, Taekjip Ha, Jie Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b97a6563b3fc4a5b933ad000dc6e31ec
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