Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population

Abstract The number of elderly people is rapidly growing, and the proportion of elderly patients with multiple myeloma (MM) continues to increase. This study aimed to develop a frailty assessment tool based on clinical data and to estimate its feasibility in elderly patients with MM. This study anal...

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Autores principales:	Ho Sup Lee, JiHyun Lee, Jae-Cheol Jo, Sung-Hoon Jung, Je-Jung Lee, Dajung Kim, Sangjin Lee, Kevin Song
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b97aed71494f400fbcda8d5f973267d2
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spelling	oai:doaj.org-article:b97aed71494f400fbcda8d5f973267d22021-11-28T12:21:54ZDevelopment of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population10.1038/s41598-021-02433-62045-2322https://doaj.org/article/b97aed71494f400fbcda8d5f973267d22021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02433-6https://doaj.org/toc/2045-2322Abstract The number of elderly people is rapidly growing, and the proportion of elderly patients with multiple myeloma (MM) continues to increase. This study aimed to develop a frailty assessment tool based on clinical data and to estimate its feasibility in elderly patients with MM. This study analyzed data from 728 elderly transplant-ineligible patients with newly diagnosed MM who were treated between January 2010 and October 2019. Our clinical frailty index included age (< 75, and ≥ 75 years), Charlson comorbidity index (CCI; < 3 and ≥ 3), and Eastern Cooperative Oncology Group performance status score (ECOG score; 0, 1–2, and ≥ 3). Patients were classified as fit, intermediate, or frail if they had a score of 0, 1, or ≥ 2, respectively. The overall survival rates differed significantly according to frailty (fit vs. intermediate: hazard ratio [HR] = 2.41; 95% confidence interval [CI] = 1.43–4.06; P = 0.001; fit vs. frail: HR = 4.61; 95% CI = 2.74–7.77; P < 0.001 and intermediate vs. frail: HR = 1.91, 95% CI = 1.49–2.45, P < 0.001, respectively). The frail had significantly shorter EFS compared with the fit and intermediate group in our frailty index (fit vs. intermediate: HR = 1.34, 95% CI = 0.92–1.96, P = 0.132; fit vs. frail: HR = 2.06, 95% CI = 1.40–3.02, P < 0.001; and intermediate vs. frail: HR = 1.53, 95% CI = 1.22–1.92, P < 0.001, respectively). The new clinical frailty index, which is based on age, CCI, and ECOG PS, can easily assess frailty in elderly patients with MM and can be helpful in predicting survival outcomes in real world clinical setting.Ho Sup LeeJiHyun LeeJae-Cheol JoSung-Hoon JungJe-Jung LeeDajung KimSangjin LeeKevin SongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ho Sup Lee JiHyun Lee Jae-Cheol Jo Sung-Hoon Jung Je-Jung Lee Dajung Kim Sangjin Lee Kevin Song Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
description	Abstract The number of elderly people is rapidly growing, and the proportion of elderly patients with multiple myeloma (MM) continues to increase. This study aimed to develop a frailty assessment tool based on clinical data and to estimate its feasibility in elderly patients with MM. This study analyzed data from 728 elderly transplant-ineligible patients with newly diagnosed MM who were treated between January 2010 and October 2019. Our clinical frailty index included age (< 75, and ≥ 75 years), Charlson comorbidity index (CCI; < 3 and ≥ 3), and Eastern Cooperative Oncology Group performance status score (ECOG score; 0, 1–2, and ≥ 3). Patients were classified as fit, intermediate, or frail if they had a score of 0, 1, or ≥ 2, respectively. The overall survival rates differed significantly according to frailty (fit vs. intermediate: hazard ratio [HR] = 2.41; 95% confidence interval [CI] = 1.43–4.06; P = 0.001; fit vs. frail: HR = 4.61; 95% CI = 2.74–7.77; P < 0.001 and intermediate vs. frail: HR = 1.91, 95% CI = 1.49–2.45, P < 0.001, respectively). The frail had significantly shorter EFS compared with the fit and intermediate group in our frailty index (fit vs. intermediate: HR = 1.34, 95% CI = 0.92–1.96, P = 0.132; fit vs. frail: HR = 2.06, 95% CI = 1.40–3.02, P < 0.001; and intermediate vs. frail: HR = 1.53, 95% CI = 1.22–1.92, P < 0.001, respectively). The new clinical frailty index, which is based on age, CCI, and ECOG PS, can easily assess frailty in elderly patients with MM and can be helpful in predicting survival outcomes in real world clinical setting.
format	article
author	Ho Sup Lee JiHyun Lee Jae-Cheol Jo Sung-Hoon Jung Je-Jung Lee Dajung Kim Sangjin Lee Kevin Song
author_facet	Ho Sup Lee JiHyun Lee Jae-Cheol Jo Sung-Hoon Jung Je-Jung Lee Dajung Kim Sangjin Lee Kevin Song
author_sort	Ho Sup Lee
title	Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
title_short	Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
title_full	Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
title_fullStr	Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
title_full_unstemmed	Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population
title_sort	development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in asian population
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b97aed71494f400fbcda8d5f973267d2
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Development of a new clinical index to easily assess frailty of elderly patients with multiple myeloma in Asian population

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