Applicability of minimally invasive surgery for clinically T4 colorectal cancer

Abstract The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MI...

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Autores principales:	Yu-Tso Liao, Jin-Tung Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b97bd136fa064113813365b6d094fc92
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spelling	oai:doaj.org-article:b97bd136fa064113813365b6d094fc922021-12-02T15:10:05ZApplicability of minimally invasive surgery for clinically T4 colorectal cancer10.1038/s41598-020-77317-22045-2322https://doaj.org/article/b97bd136fa064113813365b6d094fc922020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77317-2https://doaj.org/toc/2045-2322Abstract The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MIS at a university hospital and its branch. Patients’ demography, clinicopathology, surgical and oncological outcomes, and radicality were analyzed. A total of 128 patients were recruited with an average follow-up period of 33.8 months. The median time to soft diet was 6 days, and the median postoperative hospitalization periods was 11 days. The conversion and complication (Clavien–Dindo classification ≥ II) rates were 7.8% and 27.3%, respectively. The 30-day mortality was 0.78%. R0 resection rate was 92.2% for cT4M0 and 88.6% for pT4M0 patients. For cT4 CRC patients, the disease-free survival and 3-year overall survival were 86.1% and 86.8% for stage II, 54.1% and 57.9% for stage III, and 10.8% and 17.8% for stage IV. With acceptable conversion, complication and mortality rate, MIS may achieve satisfactory R0 resection rate and thus lead to good oncological outcomes for selected patients with cT4 CRC.Yu-Tso LiaoJin-Tung LiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu-Tso Liao Jin-Tung Liang Applicability of minimally invasive surgery for clinically T4 colorectal cancer
description	Abstract The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MIS at a university hospital and its branch. Patients’ demography, clinicopathology, surgical and oncological outcomes, and radicality were analyzed. A total of 128 patients were recruited with an average follow-up period of 33.8 months. The median time to soft diet was 6 days, and the median postoperative hospitalization periods was 11 days. The conversion and complication (Clavien–Dindo classification ≥ II) rates were 7.8% and 27.3%, respectively. The 30-day mortality was 0.78%. R0 resection rate was 92.2% for cT4M0 and 88.6% for pT4M0 patients. For cT4 CRC patients, the disease-free survival and 3-year overall survival were 86.1% and 86.8% for stage II, 54.1% and 57.9% for stage III, and 10.8% and 17.8% for stage IV. With acceptable conversion, complication and mortality rate, MIS may achieve satisfactory R0 resection rate and thus lead to good oncological outcomes for selected patients with cT4 CRC.
format	article
author	Yu-Tso Liao Jin-Tung Liang
author_facet	Yu-Tso Liao Jin-Tung Liang
author_sort	Yu-Tso Liao
title	Applicability of minimally invasive surgery for clinically T4 colorectal cancer
title_short	Applicability of minimally invasive surgery for clinically T4 colorectal cancer
title_full	Applicability of minimally invasive surgery for clinically T4 colorectal cancer
title_fullStr	Applicability of minimally invasive surgery for clinically T4 colorectal cancer
title_full_unstemmed	Applicability of minimally invasive surgery for clinically T4 colorectal cancer
title_sort	applicability of minimally invasive surgery for clinically t4 colorectal cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b97bd136fa064113813365b6d094fc92
work_keys_str_mv	AT yutsoliao applicabilityofminimallyinvasivesurgeryforclinicallyt4colorectalcancer AT jintungliang applicabilityofminimallyinvasivesurgeryforclinicallyt4colorectalcancer
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Applicability of minimally invasive surgery for clinically T4 colorectal cancer

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