Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

Huperzine A (HupA), an alkaloid found in the club moss <i>Huperzia serrata</i>, has been used for centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been attributed to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), acting a...

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Autores principales:	María Jesús Friedli, Nibaldo C. Inestrosa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	neurodegenerative diseases huperzine AChEI Alzheimer’s disease therapeutic potential neuroinflammation Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/b97d2760332445d09a45773348ce88fc
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spelling	oai:doaj.org-article:b97d2760332445d09a45773348ce88fc2021-11-11T18:31:17ZHuperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease10.3390/molecules262165311420-3049https://doaj.org/article/b97d2760332445d09a45773348ce88fc2021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6531https://doaj.org/toc/1420-3049Huperzine A (HupA), an alkaloid found in the club moss <i>Huperzia serrata</i>, has been used for centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been attributed to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), acting as an acetylcholinesterase inhibitor (AChEI). The biological functions of HupA have been studied both in vitro and in vivo, and its role in neuroprotection appears to be a good therapeutic candidate for Alzheimer´s disease (AD). Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenues, such as the Wnt signaling, the pre- and post-synaptic region mechanisms (synaptotagmin, neuroligins), the amyloid precursor protein (APP) processing, the amyloid-β peptide (Aβ) accumulation, and mitochondrial protection. Our goal is to provide an integrated overview of the molecular mechanisms through which HupA affects AD.María Jesús FriedliNibaldo C. InestrosaMDPI AGarticleneurodegenerative diseaseshuperzineAChEIAlzheimer’s diseasetherapeutic potentialneuroinflammationOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6531, p 6531 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurodegenerative diseases huperzine AChEI Alzheimer’s disease therapeutic potential neuroinflammation Organic chemistry QD241-441
spellingShingle	neurodegenerative diseases huperzine AChEI Alzheimer’s disease therapeutic potential neuroinflammation Organic chemistry QD241-441 María Jesús Friedli Nibaldo C. Inestrosa Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
description	Huperzine A (HupA), an alkaloid found in the club moss <i>Huperzia serrata</i>, has been used for centuries in Chinese folk medicine to treat dementia. The effects of this alkaloid have been attributed to its ability to inhibit the cholinergic enzyme acetylcholinesterase (AChE), acting as an acetylcholinesterase inhibitor (AChEI). The biological functions of HupA have been studied both in vitro and in vivo, and its role in neuroprotection appears to be a good therapeutic candidate for Alzheimer´s disease (AD). Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenues, such as the Wnt signaling, the pre- and post-synaptic region mechanisms (synaptotagmin, neuroligins), the amyloid precursor protein (APP) processing, the amyloid-β peptide (Aβ) accumulation, and mitochondrial protection. Our goal is to provide an integrated overview of the molecular mechanisms through which HupA affects AD.
format	article
author	María Jesús Friedli Nibaldo C. Inestrosa
author_facet	María Jesús Friedli Nibaldo C. Inestrosa
author_sort	María Jesús Friedli
title	Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
title_short	Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
title_full	Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
title_fullStr	Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
title_full_unstemmed	Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
title_sort	huperzine a and its neuroprotective molecular signaling in alzheimer’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b97d2760332445d09a45773348ce88fc
work_keys_str_mv	AT mariajesusfriedli huperzineaanditsneuroprotectivemolecularsignalinginalzheimersdisease AT nibaldocinestrosa huperzineaanditsneuroprotectivemolecularsignalinginalzheimersdisease
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Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease

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