Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011.
Case reports of Apophysomyces spp. in immunocompetent hosts have been a result of traumatic deep implantation of Apophysomyces spp. spore-contaminated soil or debris. On May 22, 2011 a tornado occurred in Joplin, MO, leaving 13 tornado victims with Apophysomyces trapeziformis infections as a result...
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Public Library of Science (PLoS)
2012
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b97ec3d4fc8742779e32967c9b1cdc06 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b97ec3d4fc8742779e32967c9b1cdc06 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b97ec3d4fc8742779e32967c9b1cdc062021-11-18T08:07:29ZWhole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011.1932-620310.1371/journal.pone.0049989https://doaj.org/article/b97ec3d4fc8742779e32967c9b1cdc062012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23209631/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Case reports of Apophysomyces spp. in immunocompetent hosts have been a result of traumatic deep implantation of Apophysomyces spp. spore-contaminated soil or debris. On May 22, 2011 a tornado occurred in Joplin, MO, leaving 13 tornado victims with Apophysomyces trapeziformis infections as a result of lacerations from airborne material. We used whole genome sequence typing (WGST) for high-resolution phylogenetic SNP analysis of 17 outbreak Apophysomyces isolates and five additional temporally and spatially diverse Apophysomyces control isolates (three A. trapeziformis and two A. variabilis isolates). Whole genome SNP phylogenetic analysis revealed three clusters of genotypically related or identical A. trapeziformis isolates and multiple distinct isolates among the Joplin group; this indicated multiple genotypes from a single or multiple sources. Though no linkage between genotype and location of exposure was observed, WGST analysis determined that the Joplin isolates were more closely related to each other than to the control isolates, suggesting local population structure. Additionally, species delineation based on WGST demonstrated the need to reassess currently accepted taxonomic classifications of phylogenetic species within the genus Apophysomyces.Kizee A EtienneJohn GilleceRemy HilsabeckJim M SchuppRebecca ColmanShawn R LockhartLalitha GadeElizabeth H ThompsonDeanna A SuttonRobyn Neblett-FanfairBenjamin J ParkGeorge TurabelidzePaul KeimMary E BrandtEszter DeakDavid M EngelthalerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49989 (2012) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Kizee A Etienne John Gillece Remy Hilsabeck Jim M Schupp Rebecca Colman Shawn R Lockhart Lalitha Gade Elizabeth H Thompson Deanna A Sutton Robyn Neblett-Fanfair Benjamin J Park George Turabelidze Paul Keim Mary E Brandt Eszter Deak David M Engelthaler Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| description |
Case reports of Apophysomyces spp. in immunocompetent hosts have been a result of traumatic deep implantation of Apophysomyces spp. spore-contaminated soil or debris. On May 22, 2011 a tornado occurred in Joplin, MO, leaving 13 tornado victims with Apophysomyces trapeziformis infections as a result of lacerations from airborne material. We used whole genome sequence typing (WGST) for high-resolution phylogenetic SNP analysis of 17 outbreak Apophysomyces isolates and five additional temporally and spatially diverse Apophysomyces control isolates (three A. trapeziformis and two A. variabilis isolates). Whole genome SNP phylogenetic analysis revealed three clusters of genotypically related or identical A. trapeziformis isolates and multiple distinct isolates among the Joplin group; this indicated multiple genotypes from a single or multiple sources. Though no linkage between genotype and location of exposure was observed, WGST analysis determined that the Joplin isolates were more closely related to each other than to the control isolates, suggesting local population structure. Additionally, species delineation based on WGST demonstrated the need to reassess currently accepted taxonomic classifications of phylogenetic species within the genus Apophysomyces. |
| format |
article |
| author |
Kizee A Etienne John Gillece Remy Hilsabeck Jim M Schupp Rebecca Colman Shawn R Lockhart Lalitha Gade Elizabeth H Thompson Deanna A Sutton Robyn Neblett-Fanfair Benjamin J Park George Turabelidze Paul Keim Mary E Brandt Eszter Deak David M Engelthaler |
| author_facet |
Kizee A Etienne John Gillece Remy Hilsabeck Jim M Schupp Rebecca Colman Shawn R Lockhart Lalitha Gade Elizabeth H Thompson Deanna A Sutton Robyn Neblett-Fanfair Benjamin J Park George Turabelidze Paul Keim Mary E Brandt Eszter Deak David M Engelthaler |
| author_sort |
Kizee A Etienne |
| title |
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| title_short |
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| title_full |
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| title_fullStr |
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| title_full_unstemmed |
Whole genome sequence typing to investigate the Apophysomyces outbreak following a tornado in Joplin, Missouri, 2011. |
| title_sort |
whole genome sequence typing to investigate the apophysomyces outbreak following a tornado in joplin, missouri, 2011. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2012 |
| url |
https://doaj.org/article/b97ec3d4fc8742779e32967c9b1cdc06 |
| work_keys_str_mv |
AT kizeeaetienne wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT johngillece wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT remyhilsabeck wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT jimmschupp wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT rebeccacolman wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT shawnrlockhart wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT lalithagade wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT elizabethhthompson wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT deannaasutton wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT robynneblettfanfair wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT benjaminjpark wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT georgeturabelidze wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT paulkeim wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT maryebrandt wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT eszterdeak wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 AT davidmengelthaler wholegenomesequencetypingtoinvestigatetheapophysomycesoutbreakfollowingatornadoinjoplinmissouri2011 |
| _version_ |
1718422189846298624 |