Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.

Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in many hospital settings, including nursing homes. It is an important nosocomial pathogen that causes mortality and an economic burden to patients, hospitals, and the community. The epidemiology of the bacteria in nursing homes is both h...

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Autores principales:	Farida Chamchod, Shigui Ruan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b97fec743f23411294187eac66d1b8c6
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spelling	oai:doaj.org-article:b97fec743f23411294187eac66d1b8c62021-11-18T07:30:46ZModeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.1932-620310.1371/journal.pone.0029757https://doaj.org/article/b97fec743f23411294187eac66d1b8c62012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22238650/?tool=EBIhttps://doaj.org/toc/1932-6203Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in many hospital settings, including nursing homes. It is an important nosocomial pathogen that causes mortality and an economic burden to patients, hospitals, and the community. The epidemiology of the bacteria in nursing homes is both hospital- and community-like. Transmission occurs via hands of health care workers (HCWs) and direct contacts among residents during social activities. In this work, mathematical modeling in both deterministic and stochastic frameworks is used to study dissemination of MRSA among residents and HCWs, persistence and prevalence of MRSA in a population, and possible means of controlling the spread of this pathogen in nursing homes. The model predicts that: (i) without strict screening and decolonization of colonized individuals at admission, MRSA may persist; (ii) decolonization of colonized residents, improving hand hygiene in both residents and HCWs, reducing the duration of contamination of HCWs, and decreasing the resident∶staff ratio are possible control strategies; (iii) the mean time that a resident remains susceptible since admission may be prolonged by screening and decolonization treatment in colonized individuals; (iv) in the stochastic framework, the total number of colonized residents varies and may increase when the admission of colonized residents, the duration of colonization, the average number of contacts among residents, or the average number of contacts that each resident requires from HCWs increases; (v) an introduction of a colonized individual into an MRSA-free nursing home has a much higher probability of leading to a major outbreak taking off than an introduction of a contaminated HCW.Farida ChamchodShigui RuanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29757 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Farida Chamchod Shigui Ruan Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
description	Methicillin-resistant Staphylococcus aureus (MRSA) is endemic in many hospital settings, including nursing homes. It is an important nosocomial pathogen that causes mortality and an economic burden to patients, hospitals, and the community. The epidemiology of the bacteria in nursing homes is both hospital- and community-like. Transmission occurs via hands of health care workers (HCWs) and direct contacts among residents during social activities. In this work, mathematical modeling in both deterministic and stochastic frameworks is used to study dissemination of MRSA among residents and HCWs, persistence and prevalence of MRSA in a population, and possible means of controlling the spread of this pathogen in nursing homes. The model predicts that: (i) without strict screening and decolonization of colonized individuals at admission, MRSA may persist; (ii) decolonization of colonized residents, improving hand hygiene in both residents and HCWs, reducing the duration of contamination of HCWs, and decreasing the resident∶staff ratio are possible control strategies; (iii) the mean time that a resident remains susceptible since admission may be prolonged by screening and decolonization treatment in colonized individuals; (iv) in the stochastic framework, the total number of colonized residents varies and may increase when the admission of colonized residents, the duration of colonization, the average number of contacts among residents, or the average number of contacts that each resident requires from HCWs increases; (v) an introduction of a colonized individual into an MRSA-free nursing home has a much higher probability of leading to a major outbreak taking off than an introduction of a contaminated HCW.
format	article
author	Farida Chamchod Shigui Ruan
author_facet	Farida Chamchod Shigui Ruan
author_sort	Farida Chamchod
title	Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
title_short	Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
title_full	Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
title_fullStr	Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
title_full_unstemmed	Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.
title_sort	modeling the spread of methicillin-resistant staphylococcus aureus in nursing homes for elderly.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/b97fec743f23411294187eac66d1b8c6
work_keys_str_mv	AT faridachamchod modelingthespreadofmethicillinresistantstaphylococcusaureusinnursinghomesforelderly AT shiguiruan modelingthespreadofmethicillinresistantstaphylococcusaureusinnursinghomesforelderly
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Modeling the spread of methicillin-resistant Staphylococcus aureus in nursing homes for elderly.

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