Corneal sensitivity after topical bromfenac sodium eye-drop instillation

Kaori Yanai,1 Jane Huang,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan; 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: To evaluate the safety of bromfenac sodium eye drops from...

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Autores principales:	Yanai K, Huang J, Kadonosono K, Uchio E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b980e488a1c9442e8b92165d85fd991d
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spelling	oai:doaj.org-article:b980e488a1c9442e8b92165d85fd991d2021-12-02T09:23:14ZCorneal sensitivity after topical bromfenac sodium eye-drop instillation1177-54671177-5483https://doaj.org/article/b980e488a1c9442e8b92165d85fd991d2013-04-01T00:00:00Zhttp://www.dovepress.com/corneal-sensitivity-after-topical-bromfenac-sodium-eye-drop-instillati-a12786https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Kaori Yanai,1 Jane Huang,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan; 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: To evaluate the safety of bromfenac sodium eye drops from the standpoint of corneal sensitivity and tear secretion in healthy controls following instillation for 1 month. Methods: A prospective single-blind parallel clinical study was conducted in 20 eyes of ten healthy volunteers with no history of ocular or systemic allergic disease, dry eye, contact lens wear, or ocular surgery. Participants were instructed to instill either bromfenac sodium or artificial tears in each eye twice daily for 28 days. Corneal sensitivity tested using a Cochet–Bonnet esthesiometer was evaluated before and immediately after instillation at 7, 14, and 28 days after the initiation of treatment. Tear secretion was also evaluated by Schirmer's eye test before and at 28 days. Results: No significant difference in mean corneal sensitivity and tear-secretion rate was observed between the bromfenac and artificial-tear treatment groups at any time. Conclusion: These results indicate that bromfenac sodium eye drops are safe with respect to corneal sensitivity and tear secretion in subjects with a normal ocular surface condition. Further evaluation is still necessary to determine whether bromfenac is safe in pathological conditions, such as inflammatory disorders and postsurgical cases. Keywords: bromfenac sodium, cornea, sensitivity, tear, nonsteroidal anti-inflammatory drugYanai KHuang JKadonosono KUchio EDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 741-744 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yanai K Huang J Kadonosono K Uchio E Corneal sensitivity after topical bromfenac sodium eye-drop instillation
description	Kaori Yanai,1 Jane Huang,1 Kazuaki Kadonosono,2 Eiichi Uchio1 1Department of Ophthalmology, Fukuoka University School of Medicine, Fukuoka, Japan; 2Department of Ophthalmology, Yokohama City University Medical Center, Yokohama, Japan Purpose: To evaluate the safety of bromfenac sodium eye drops from the standpoint of corneal sensitivity and tear secretion in healthy controls following instillation for 1 month. Methods: A prospective single-blind parallel clinical study was conducted in 20 eyes of ten healthy volunteers with no history of ocular or systemic allergic disease, dry eye, contact lens wear, or ocular surgery. Participants were instructed to instill either bromfenac sodium or artificial tears in each eye twice daily for 28 days. Corneal sensitivity tested using a Cochet–Bonnet esthesiometer was evaluated before and immediately after instillation at 7, 14, and 28 days after the initiation of treatment. Tear secretion was also evaluated by Schirmer's eye test before and at 28 days. Results: No significant difference in mean corneal sensitivity and tear-secretion rate was observed between the bromfenac and artificial-tear treatment groups at any time. Conclusion: These results indicate that bromfenac sodium eye drops are safe with respect to corneal sensitivity and tear secretion in subjects with a normal ocular surface condition. Further evaluation is still necessary to determine whether bromfenac is safe in pathological conditions, such as inflammatory disorders and postsurgical cases. Keywords: bromfenac sodium, cornea, sensitivity, tear, nonsteroidal anti-inflammatory drug
format	article
author	Yanai K Huang J Kadonosono K Uchio E
author_facet	Yanai K Huang J Kadonosono K Uchio E
author_sort	Yanai K
title	Corneal sensitivity after topical bromfenac sodium eye-drop instillation
title_short	Corneal sensitivity after topical bromfenac sodium eye-drop instillation
title_full	Corneal sensitivity after topical bromfenac sodium eye-drop instillation
title_fullStr	Corneal sensitivity after topical bromfenac sodium eye-drop instillation
title_full_unstemmed	Corneal sensitivity after topical bromfenac sodium eye-drop instillation
title_sort	corneal sensitivity after topical bromfenac sodium eye-drop instillation
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/b980e488a1c9442e8b92165d85fd991d
work_keys_str_mv	AT yanaik cornealsensitivityaftertopicalbromfenacsodiumeyedropinstillation AT huangj cornealsensitivityaftertopicalbromfenacsodiumeyedropinstillation AT kadonosonok cornealsensitivityaftertopicalbromfenacsodiumeyedropinstillation AT uchioe cornealsensitivityaftertopicalbromfenacsodiumeyedropinstillation
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Corneal sensitivity after topical bromfenac sodium eye-drop instillation

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