Long-term changes in the small-world organization of brain networks after concussion

Abstract There is a growing body of literature using functional MRI to study the acute and long-term effects of concussion on functional brain networks. To date, studies have largely focused on changes in pairwise connectivity strength between brain regions. Less is known about how concussion affect...

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Autores principales:	N. W. Churchill, M. G. Hutchison, S. J. Graham, T. A. Schweizer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9811479f542444e87ff47ee5d4564a7
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spelling	oai:doaj.org-article:b9811479f542444e87ff47ee5d4564a72021-12-02T17:04:06ZLong-term changes in the small-world organization of brain networks after concussion10.1038/s41598-021-85811-42045-2322https://doaj.org/article/b9811479f542444e87ff47ee5d4564a72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85811-4https://doaj.org/toc/2045-2322Abstract There is a growing body of literature using functional MRI to study the acute and long-term effects of concussion on functional brain networks. To date, studies have largely focused on changes in pairwise connectivity strength between brain regions. Less is known about how concussion affects whole-brain network topology, particularly the “small-world” organization which facilitates efficient communication at both local and global scales. The present study addressed this knowledge gap by measuring local and global efficiency of 26 concussed athletes at acute injury, return to play (RTP) and one year post-RTP, along with a cohort of 167 athletic controls. On average, concussed athletes showed no alterations in local efficiency but had elevated global efficiency at acute injury, which had resolved by RTP. Athletes with atypically long recovery, however, had reduced global efficiency at 1 year post-RTP, suggesting long-term functional abnormalities for this subgroup. Analyses of nodal efficiency further indicated that global network changes were driven by high-efficiency visual and sensorimotor regions and low-efficiency frontal and subcortical regions. This study provides evidence that concussion causes subtle acute and long-term changes in the small-world organization of the brain, with effects that are related to the clinical profile of recovery.N. W. ChurchillM. G. HutchisonS. J. GrahamT. A. SchweizerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q N. W. Churchill M. G. Hutchison S. J. Graham T. A. Schweizer Long-term changes in the small-world organization of brain networks after concussion
description	Abstract There is a growing body of literature using functional MRI to study the acute and long-term effects of concussion on functional brain networks. To date, studies have largely focused on changes in pairwise connectivity strength between brain regions. Less is known about how concussion affects whole-brain network topology, particularly the “small-world” organization which facilitates efficient communication at both local and global scales. The present study addressed this knowledge gap by measuring local and global efficiency of 26 concussed athletes at acute injury, return to play (RTP) and one year post-RTP, along with a cohort of 167 athletic controls. On average, concussed athletes showed no alterations in local efficiency but had elevated global efficiency at acute injury, which had resolved by RTP. Athletes with atypically long recovery, however, had reduced global efficiency at 1 year post-RTP, suggesting long-term functional abnormalities for this subgroup. Analyses of nodal efficiency further indicated that global network changes were driven by high-efficiency visual and sensorimotor regions and low-efficiency frontal and subcortical regions. This study provides evidence that concussion causes subtle acute and long-term changes in the small-world organization of the brain, with effects that are related to the clinical profile of recovery.
format	article
author	N. W. Churchill M. G. Hutchison S. J. Graham T. A. Schweizer
author_facet	N. W. Churchill M. G. Hutchison S. J. Graham T. A. Schweizer
author_sort	N. W. Churchill
title	Long-term changes in the small-world organization of brain networks after concussion
title_short	Long-term changes in the small-world organization of brain networks after concussion
title_full	Long-term changes in the small-world organization of brain networks after concussion
title_fullStr	Long-term changes in the small-world organization of brain networks after concussion
title_full_unstemmed	Long-term changes in the small-world organization of brain networks after concussion
title_sort	long-term changes in the small-world organization of brain networks after concussion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9811479f542444e87ff47ee5d4564a7
work_keys_str_mv	AT nwchurchill longtermchangesinthesmallworldorganizationofbrainnetworksafterconcussion AT mghutchison longtermchangesinthesmallworldorganizationofbrainnetworksafterconcussion AT sjgraham longtermchangesinthesmallworldorganizationofbrainnetworksafterconcussion AT taschweizer longtermchangesinthesmallworldorganizationofbrainnetworksafterconcussion
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Long-term changes in the small-world organization of brain networks after concussion

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