Flexible simultaneous mesoscale two-photon imaging of neural activity at high speeds

Functional brain imaging with two-photon microscopy is limited by a tradeoff between imaging area and acquisition speed. Here, the authors present Quadroscope, a flexible microscope which allows for simultaneous video rate acquisition of four independently targetable brain regions across 5 mm.

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Detalles Bibliográficos
Autores principales: Mitchell Clough, Ichun Anderson Chen, Seong-Wook Park, Allison M. Ahrens, Jeffrey N. Stirman, Spencer L. Smith, Jerry L. Chen
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b981c71532914106a9b1e5778371edc0
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Sumario:Functional brain imaging with two-photon microscopy is limited by a tradeoff between imaging area and acquisition speed. Here, the authors present Quadroscope, a flexible microscope which allows for simultaneous video rate acquisition of four independently targetable brain regions across 5 mm.