Factors Determining the Morphology of Peripapillary Retinoschisis

Reimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye C...

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Autores principales:	Nishijima R, Ogawa S, Nishijima E, Itoh Y, Yoshikawa K, Nakano T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	peripapillary retinoschisis optical coherent tomography glaucoma myopia Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/b981cc8da14245e09c45d572b31d9bbc
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spelling	oai:doaj.org-article:b981cc8da14245e09c45d572b31d9bbc2021-12-02T14:02:58ZFactors Determining the Morphology of Peripapillary Retinoschisis1177-5483https://doaj.org/article/b981cc8da14245e09c45d572b31d9bbc2021-03-01T00:00:00Zhttps://www.dovepress.com/factors-determining-the-morphology-of-peripapillary-retinoschisis-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Reimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye Clinic, Machida-city, Tokyo, JapanCorrespondence: Shumpei OgawaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8471, JapanTel +813 3433 1111Fax +813 3433 1936Email shmp0722@gmail.comPurpose: We conducted cross-sectional examinations to determine the frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the pathogenesis of PRS by using spectral-domain optical coherence tomography (SD-OCT).Patients and Methods: In 1516 cases involving glaucoma and suspected glaucoma, we retrospectively reviewed the disc and macular volume scans obtained by SD-OCT and categorized PRS into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch’s membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.Results: The total frequency of PRS was 1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS was detected in the outer layers (inner nuclear layer: 10%, outer plexiform layer: 20%, outer nuclear layer: 50%). In addition, the eyes in the ahead group had significantly greater axial lengths and significantly smaller spherical equivalent values. These two differences suggest that the pulling force of the vitreous traction may play an important role in PRS only in the behind group and that the scleral stretching force may play a role in the development of PRS in the ahead group.Conclusion: The frequency of PRS in patients with POAG is higher than that in patients with suspected glaucoma. Both forms of PRS are affected by posterior vitreous detachment and axial length elongation. Careful follow-up is required to assess the development of PRS in glaucoma suspects. The pathogenesis of PRS has been elucidated to some degree by classifying the morphological condition of the PRS and BMO.Keywords: peripapillary retinoschisis, optical coherent tomography, glaucoma, myopiaNishijima ROgawa SNishijima EItoh YYoshikawa KNakano TDove Medical Pressarticleperipapillary retinoschisisoptical coherent tomographyglaucomamyopiaOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1293-1300 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	peripapillary retinoschisis optical coherent tomography glaucoma myopia Ophthalmology RE1-994
spellingShingle	peripapillary retinoschisis optical coherent tomography glaucoma myopia Ophthalmology RE1-994 Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T Factors Determining the Morphology of Peripapillary Retinoschisis
description	Reimi Nishijima,1,2 Shumpei Ogawa,1 Euido Nishijima,1 Yoshinori Itoh,1 Keiji Yoshikawa,1,3 Tadashi Nakano1 1Department of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology, The Jikei University Katsushika Medical Center, Tokyo, Japan; 3Yoshikawa Eye Clinic, Machida-city, Tokyo, JapanCorrespondence: Shumpei OgawaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8471, JapanTel +813 3433 1111Fax +813 3433 1936Email shmp0722@gmail.comPurpose: We conducted cross-sectional examinations to determine the frequency of peripapillary retinoschisis (PRS) in eyes with glaucoma and suspected glaucoma and analyzed the pathogenesis of PRS by using spectral-domain optical coherence tomography (SD-OCT).Patients and Methods: In 1516 cases involving glaucoma and suspected glaucoma, we retrospectively reviewed the disc and macular volume scans obtained by SD-OCT and categorized PRS into two groups based on whether the retinoschisis was closer to the optic nerve over the Bruch’s membrane opening (BMO) (ahead group) or did not go past the BMO (behind group) and then compared the characteristics between both groups.Results: The total frequency of PRS was 1.49% (20/1342 eyes) in primary open-angle glaucoma (POAG) eyes and 0.59% (10/1687 eyes) in glaucoma suspects. In the behind group, PRS was mostly detected in the inner layers of the retina (retinal nerve fiber layer: 30.9%, ganglion cell layer: 21.8%, inner plexiform layer: 7.3%). However, in the ahead group, PRS was detected in the outer layers (inner nuclear layer: 10%, outer plexiform layer: 20%, outer nuclear layer: 50%). In addition, the eyes in the ahead group had significantly greater axial lengths and significantly smaller spherical equivalent values. These two differences suggest that the pulling force of the vitreous traction may play an important role in PRS only in the behind group and that the scleral stretching force may play a role in the development of PRS in the ahead group.Conclusion: The frequency of PRS in patients with POAG is higher than that in patients with suspected glaucoma. Both forms of PRS are affected by posterior vitreous detachment and axial length elongation. Careful follow-up is required to assess the development of PRS in glaucoma suspects. The pathogenesis of PRS has been elucidated to some degree by classifying the morphological condition of the PRS and BMO.Keywords: peripapillary retinoschisis, optical coherent tomography, glaucoma, myopia
format	article
author	Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T
author_facet	Nishijima R Ogawa S Nishijima E Itoh Y Yoshikawa K Nakano T
author_sort	Nishijima R
title	Factors Determining the Morphology of Peripapillary Retinoschisis
title_short	Factors Determining the Morphology of Peripapillary Retinoschisis
title_full	Factors Determining the Morphology of Peripapillary Retinoschisis
title_fullStr	Factors Determining the Morphology of Peripapillary Retinoschisis
title_full_unstemmed	Factors Determining the Morphology of Peripapillary Retinoschisis
title_sort	factors determining the morphology of peripapillary retinoschisis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/b981cc8da14245e09c45d572b31d9bbc
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Factors Determining the Morphology of Peripapillary Retinoschisis

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