Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge

Over the course of human history, billions of people worldwide have been infected by various viruses. Despite rapid progress in the development of biomedical techniques, it is still a significant challenge to find promising new antiviral targets and drugs. In the past, antiviral drugs mainly targete...

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Autores principales:	Xuan Xu, Qing-Ye Zhang, Xin-Yi Chu, Yuan Quan, Bo-Min Lv, Hong-Yu Zhang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	genetics evolution host receptors Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b984cdd4471a4579aa7553bc8ff59e09
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spelling	oai:doaj.org-article:b984cdd4471a4579aa7553bc8ff59e092021-11-25T19:12:23ZFacilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge10.3390/v131121171999-4915https://doaj.org/article/b984cdd4471a4579aa7553bc8ff59e092021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2117https://doaj.org/toc/1999-4915Over the course of human history, billions of people worldwide have been infected by various viruses. Despite rapid progress in the development of biomedical techniques, it is still a significant challenge to find promising new antiviral targets and drugs. In the past, antiviral drugs mainly targeted viral proteins when they were used as part of treatment strategies. Since the virus mutation rate is much faster than that of the host, such drugs feature drug resistance and narrow-spectrum antiviral problems. Therefore, the targeting of host molecules has gradually become an important area of research for the development of antiviral drugs. In recent years, rapid advances in high-throughput sequencing techniques have enabled numerous genetic studies (such as genome-wide association studies (GWAS), clustered regularly interspersed short palindromic repeats (CRISPR) screening, etc.) for human diseases, providing valuable genetic and evolutionary resources. Furthermore, it has been revealed that successful drug targets exhibit similar genetic and evolutionary features, which are of great value in identifying promising drug targets and discovering new drugs. Considering these developments, in this article the authors propose a host-targeted antiviral drug discovery strategy based on knowledge of genetics and evolution. We first comprehensively summarized the genetic, subcellular location, and evolutionary features of the human genes that have been successfully used as antiviral targets. Next, the summarized features were used to screen novel druggable antiviral targets and to find potential antiviral drugs, in an attempt to promote the discovery of new antiviral drugs.Xuan XuQing-Ye ZhangXin-Yi ChuYuan QuanBo-Min LvHong-Yu ZhangMDPI AGarticlegeneticsevolutionhost receptorsMicrobiologyQR1-502ENViruses, Vol 13, Iss 2117, p 2117 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	genetics evolution host receptors Microbiology QR1-502
spellingShingle	genetics evolution host receptors Microbiology QR1-502 Xuan Xu Qing-Ye Zhang Xin-Yi Chu Yuan Quan Bo-Min Lv Hong-Yu Zhang Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
description	Over the course of human history, billions of people worldwide have been infected by various viruses. Despite rapid progress in the development of biomedical techniques, it is still a significant challenge to find promising new antiviral targets and drugs. In the past, antiviral drugs mainly targeted viral proteins when they were used as part of treatment strategies. Since the virus mutation rate is much faster than that of the host, such drugs feature drug resistance and narrow-spectrum antiviral problems. Therefore, the targeting of host molecules has gradually become an important area of research for the development of antiviral drugs. In recent years, rapid advances in high-throughput sequencing techniques have enabled numerous genetic studies (such as genome-wide association studies (GWAS), clustered regularly interspersed short palindromic repeats (CRISPR) screening, etc.) for human diseases, providing valuable genetic and evolutionary resources. Furthermore, it has been revealed that successful drug targets exhibit similar genetic and evolutionary features, which are of great value in identifying promising drug targets and discovering new drugs. Considering these developments, in this article the authors propose a host-targeted antiviral drug discovery strategy based on knowledge of genetics and evolution. We first comprehensively summarized the genetic, subcellular location, and evolutionary features of the human genes that have been successfully used as antiviral targets. Next, the summarized features were used to screen novel druggable antiviral targets and to find potential antiviral drugs, in an attempt to promote the discovery of new antiviral drugs.
format	article
author	Xuan Xu Qing-Ye Zhang Xin-Yi Chu Yuan Quan Bo-Min Lv Hong-Yu Zhang
author_facet	Xuan Xu Qing-Ye Zhang Xin-Yi Chu Yuan Quan Bo-Min Lv Hong-Yu Zhang
author_sort	Xuan Xu
title	Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
title_short	Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
title_full	Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
title_fullStr	Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
title_full_unstemmed	Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge
title_sort	facilitating antiviral drug discovery using genetic and evolutionary knowledge
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b984cdd4471a4579aa7553bc8ff59e09
work_keys_str_mv	AT xuanxu facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge AT qingyezhang facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge AT xinyichu facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge AT yuanquan facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge AT bominlv facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge AT hongyuzhang facilitatingantiviraldrugdiscoveryusinggeneticandevolutionaryknowledge
_version_	1718410178239397888

Facilitating Antiviral Drug Discovery Using Genetic and Evolutionary Knowledge

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