Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

Abstract Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent p...

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Autores principales:	Jian Kang, Shuqing Liu, Yifan Song, Yaojuan Chu, Mengru Wang, Yamin Shi, Fengyan Zhang, Lin Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b985e2cd78714244b25fe43910378c27
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spelling	oai:doaj.org-article:b985e2cd78714244b25fe43910378c272021-12-02T14:49:34ZMatrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis10.1038/s41598-021-89086-72045-2322https://doaj.org/article/b985e2cd78714244b25fe43910378c272021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89086-7https://doaj.org/toc/2045-2322Abstract Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. MAT administration, started at disease onset, significantly suppressed optic nerve infiltration and demyelination, with reduced numbers of Iba1+ macrophages/microglia and CD4+ T cells, compared to those from vehicle-treated rats. Increased expression of neurofilaments, an axon marker, reduced numbers of apoptosis in retinal ganglion cells (RGCs). Moreover, MAT treatment promoted Akt phosphorylation and shifted the Bcl-2/Bax ratio back towards an antiapoptotic one, which could be a mechanism for its therapeutic effect in the ON model. Taken as a whole, our results demonstrate that MAT attenuated inflammation, demyelination and axonal loss in the optic nerve, and protected RGCs from inflammation-induced cell death. MAT may therefore have potential as a novel treatment for this disease that may result in blindness.Jian KangShuqing LiuYifan SongYaojuan ChuMengru WangYamin ShiFengyan ZhangLin ZhuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Kang Shuqing Liu Yifan Song Yaojuan Chu Mengru Wang Yamin Shi Fengyan Zhang Lin Zhu Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
description	Abstract Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of visual disturbance in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. MAT administration, started at disease onset, significantly suppressed optic nerve infiltration and demyelination, with reduced numbers of Iba1+ macrophages/microglia and CD4+ T cells, compared to those from vehicle-treated rats. Increased expression of neurofilaments, an axon marker, reduced numbers of apoptosis in retinal ganglion cells (RGCs). Moreover, MAT treatment promoted Akt phosphorylation and shifted the Bcl-2/Bax ratio back towards an antiapoptotic one, which could be a mechanism for its therapeutic effect in the ON model. Taken as a whole, our results demonstrate that MAT attenuated inflammation, demyelination and axonal loss in the optic nerve, and protected RGCs from inflammation-induced cell death. MAT may therefore have potential as a novel treatment for this disease that may result in blindness.
format	article
author	Jian Kang Shuqing Liu Yifan Song Yaojuan Chu Mengru Wang Yamin Shi Fengyan Zhang Lin Zhu
author_facet	Jian Kang Shuqing Liu Yifan Song Yaojuan Chu Mengru Wang Yamin Shi Fengyan Zhang Lin Zhu
author_sort	Jian Kang
title	Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
title_short	Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
title_full	Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
title_fullStr	Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
title_full_unstemmed	Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
title_sort	matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b985e2cd78714244b25fe43910378c27
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Matrine treatment reduces retinal ganglion cell apoptosis in experimental optic neuritis

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