Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium
Hee-Seon Kim1 *, Min-Kyung Ji2 *, Woo-Hyung Jang1 *, Khurshed Alam,3 Hyun-Seung Kim,4 Hoon-Sung Cho,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea; 2Optoelectronics Convergence Research Center, Chonn...
Guardado en:
| Autores principales: | , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/b9888378d65f4437ac8db3fcb19a5f2c |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:b9888378d65f4437ac8db3fcb19a5f2c |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:b9888378d65f4437ac8db3fcb19a5f2c2021-12-02T19:22:34ZBiological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium1178-2013https://doaj.org/article/b9888378d65f4437ac8db3fcb19a5f2c2021-10-01T00:00:00Zhttps://www.dovepress.com/biological-effects-of-the-novel-mulberry-surface-characterized-by-micr-peer-reviewed-fulltext-article-IJNhttps://doaj.org/toc/1178-2013Hee-Seon Kim1 *, Min-Kyung Ji2 *, Woo-Hyung Jang1 *, Khurshed Alam,3 Hyun-Seung Kim,4 Hoon-Sung Cho,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea; 2Optoelectronics Convergence Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea; 3Department of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea; 4Department of Division of New Projects, KJ Meditech Co, Ltd, Gwangju, 61009, Republic of Korea*These authors contributed equally to this workCorrespondence: Hyun-Pil LimDepartment of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of KoreaTel +82-10-2645-7528Fax +82-62-530-5577Email mcnihil@jnu.ac.krHoon-Sung ChoDepartment of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Republic of KoreaTel +82-10-8545-2816Fax +82-62-530-1717Email cho.hoonsung@jnu.ac.krPurpose: This paper presents a technique for developing a novel surface for dental implants using a combination of nitriding and anodic oxidation, followed by the deposition of graphene oxide using atmospheric plasma. The effects of various surface treatments on bacterial adhesion and osteoblast activation were also evaluated.Methods: CP titanium (control) was processed into disk-shaped specimens. Nitriding was conducted using vacuum nitriding, followed by anodic oxidation, which was performed in an electrolyte using a DC power supply, to form the novel “mulberry surface.” Graphene oxide deposition was performed using atmospheric plasma with an inflow of carbon sources. After analyzing the sample surfaces, antibacterial activity was evaluated using Streptococcus mutans and Porphyromonas gingivalis bacteria. The viability, adhesion, proliferation, and differentiation of osteoblasts were also assessed. Analysis of variance (ANOVA) with Tukey’s post-hoc test was used to calculate statistical differences.Results: We observed that the mulberry surface was formed on samples treated with nitriding and anodic oxidation, and these samples exhibited more effective antibacterial activity than the control. We also found that the samples with additional graphene oxide deposition exhibited better biocompatibility, which was validated by osteoblast adhesion, proliferation, and differentiation.Conclusion: The development of the mulberry surface along with graphene oxide deposition inhibits bacterial adhesion to the implant and enhances the adhesion, proliferation, and differentiation of osteoblasts. These results indicate that the mulberry surface and graphene oxide deposition together can inhibit peri-implantitis and promote osseointegration.Keywords: nitriding, anodic oxidation, atmospheric plasma, biofilm formation, osteoblastsKim HSJi MKJang WHAlam KKim HSCho HSLim HPDove Medical Pressarticlenitridinganodic oxidationatmospheric plasmabiofilm formationosteoblastsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 7307-7317 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
nitriding anodic oxidation atmospheric plasma biofilm formation osteoblasts Medicine (General) R5-920 |
| spellingShingle |
nitriding anodic oxidation atmospheric plasma biofilm formation osteoblasts Medicine (General) R5-920 Kim HS Ji MK Jang WH Alam K Kim HS Cho HS Lim HP Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| description |
Hee-Seon Kim1 *, Min-Kyung Ji2 *, Woo-Hyung Jang1 *, Khurshed Alam,3 Hyun-Seung Kim,4 Hoon-Sung Cho,3 Hyun-Pil Lim1 1Department of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, Republic of Korea; 2Optoelectronics Convergence Research Center, Chonnam National University, Gwangju, 61186, Republic of Korea; 3Department of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Republic of Korea; 4Department of Division of New Projects, KJ Meditech Co, Ltd, Gwangju, 61009, Republic of Korea*These authors contributed equally to this workCorrespondence: Hyun-Pil LimDepartment of Prosthodontics, School of Dentistry, Chonnam National University, Gwangju, 61186, Republic of KoreaTel +82-10-2645-7528Fax +82-62-530-5577Email mcnihil@jnu.ac.krHoon-Sung ChoDepartment of Materials Science and Engineering, Chonnam National University, Gwangju, 61186, Republic of KoreaTel +82-10-8545-2816Fax +82-62-530-1717Email cho.hoonsung@jnu.ac.krPurpose: This paper presents a technique for developing a novel surface for dental implants using a combination of nitriding and anodic oxidation, followed by the deposition of graphene oxide using atmospheric plasma. The effects of various surface treatments on bacterial adhesion and osteoblast activation were also evaluated.Methods: CP titanium (control) was processed into disk-shaped specimens. Nitriding was conducted using vacuum nitriding, followed by anodic oxidation, which was performed in an electrolyte using a DC power supply, to form the novel “mulberry surface.” Graphene oxide deposition was performed using atmospheric plasma with an inflow of carbon sources. After analyzing the sample surfaces, antibacterial activity was evaluated using Streptococcus mutans and Porphyromonas gingivalis bacteria. The viability, adhesion, proliferation, and differentiation of osteoblasts were also assessed. Analysis of variance (ANOVA) with Tukey’s post-hoc test was used to calculate statistical differences.Results: We observed that the mulberry surface was formed on samples treated with nitriding and anodic oxidation, and these samples exhibited more effective antibacterial activity than the control. We also found that the samples with additional graphene oxide deposition exhibited better biocompatibility, which was validated by osteoblast adhesion, proliferation, and differentiation.Conclusion: The development of the mulberry surface along with graphene oxide deposition inhibits bacterial adhesion to the implant and enhances the adhesion, proliferation, and differentiation of osteoblasts. These results indicate that the mulberry surface and graphene oxide deposition together can inhibit peri-implantitis and promote osseointegration.Keywords: nitriding, anodic oxidation, atmospheric plasma, biofilm formation, osteoblasts |
| format |
article |
| author |
Kim HS Ji MK Jang WH Alam K Kim HS Cho HS Lim HP |
| author_facet |
Kim HS Ji MK Jang WH Alam K Kim HS Cho HS Lim HP |
| author_sort |
Kim HS |
| title |
Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| title_short |
Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| title_full |
Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| title_fullStr |
Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| title_full_unstemmed |
Biological Effects of the Novel Mulberry Surface Characterized by Micro/Nanopores and Plasma-Based Graphene Oxide Deposition on Titanium |
| title_sort |
biological effects of the novel mulberry surface characterized by micro/nanopores and plasma-based graphene oxide deposition on titanium |
| publisher |
Dove Medical Press |
| publishDate |
2021 |
| url |
https://doaj.org/article/b9888378d65f4437ac8db3fcb19a5f2c |
| work_keys_str_mv |
AT kimhs biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT jimk biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT jangwh biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT alamk biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT kimhs biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT chohs biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium AT limhp biologicaleffectsofthenovelmulberrysurfacecharacterizedbymicronanoporesandplasmabasedgrapheneoxidedepositionontitanium |
| _version_ |
1718376759229939712 |