THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS

Abstract. The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional properties and the potential to generate mature...

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Autores principales:	V. A. Chereshnev, O. V. Lebedinskaya, C. Yu. Rodionov, N. K. Ahmatova, I. Zh. Shubina, E. A. Lebedinskaya, T. V. Gavrilova, M. V. Kisselevsky
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	profetal α-fetoprotein mononuclear leukocytes dendritic cells immunophenotype functional activity Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b98ca6cc9be24fb5a1c34114b1894fcf
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spelling	oai:doaj.org-article:b98ca6cc9be24fb5a1c34114b1894fcf2021-11-18T08:03:43ZTHE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS1563-06252313-741X10.15789/1563-0625-2005-5-6-525-534https://doaj.org/article/b98ca6cc9be24fb5a1c34114b1894fcf2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/619https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional properties and the potential to generate mature dendritic cells (DC).Addition of the drug to cell cultures at optimal doses was shown to cause significant increase in their proliferative capacity and ML blastic transformation levels, and enhanced cytotoxicity towards K562 tumor cells, as well as to induce maturation of antigen-presenting dendritic cells.On the basis of the data obtained, a conclusion is made that 'Profetal' is an active immunomodulatory factor, and it may be applied for generation of cytotoxic lymphocytes and mature DC, aiming to apply them for the biotherapy of oncological and infectious diseases.V. A. ChereshnevO. V. LebedinskayaC. Yu. RodionovN. K. AhmatovaI. Zh. ShubinaE. A. LebedinskayaT. V. GavrilovaM. V. KisselevskySPb RAACIarticleprofetalα-fetoproteinmononuclear leukocytesdendritic cellsimmunophenotypefunctional activityImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 525-534 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	profetal α-fetoprotein mononuclear leukocytes dendritic cells immunophenotype functional activity Immunologic diseases. Allergy RC581-607
spellingShingle	profetal α-fetoprotein mononuclear leukocytes dendritic cells immunophenotype functional activity Immunologic diseases. Allergy RC581-607 V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
description	Abstract. The effects of 'Profetal', a drug containing liophylized, dextran-stabilized human alpha-fetoprotein as main active component, were investigated on peripheral donor blood mononuclear leukocytes (ML), with respect to their functional properties and the potential to generate mature dendritic cells (DC).Addition of the drug to cell cultures at optimal doses was shown to cause significant increase in their proliferative capacity and ML blastic transformation levels, and enhanced cytotoxicity towards K562 tumor cells, as well as to induce maturation of antigen-presenting dendritic cells.On the basis of the data obtained, a conclusion is made that 'Profetal' is an active immunomodulatory factor, and it may be applied for generation of cytotoxic lymphocytes and mature DC, aiming to apply them for the biotherapy of oncological and infectious diseases.
format	article
author	V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky
author_facet	V. A. Chereshnev O. V. Lebedinskaya C. Yu. Rodionov N. K. Ahmatova I. Zh. Shubina E. A. Lebedinskaya T. V. Gavrilova M. V. Kisselevsky
author_sort	V. A. Chereshnev
title	THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
title_short	THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
title_full	THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
title_fullStr	THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
title_full_unstemmed	THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS
title_sort	effects of 'profetal' preparation upon functional activity of human mononuclear leukocytes and dendritic cells
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b98ca6cc9be24fb5a1c34114b1894fcf
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THE EFFECTS OF 'PROFETAL' PREPARATION UPON FUNCTIONAL ACTIVITY OF HUMAN MONONUCLEAR LEUKOCYTES AND DENDRITIC CELLS

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