ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca2+release from the endoplasmic reticulum.

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Autores principales:	Wenbin Zhong, Qing Yi, Bing Xu, Shiqian Li, Tong Wang, Fupei Liu, Biying Zhu, Peter R. Hoffmann, Guangju Ji, Pingsheng Lei, Guoping Li, Jiwei Li, Jian Li, Vesa M. Olkkonen, Daoguang Yan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b98f458b5e1746fcbf102e2496b3b6ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:b98f458b5e1746fcbf102e2496b3b6ec2021-12-02T16:49:57ZORP4L is essential for T-cell acute lymphoblastic leukemia cell survival10.1038/ncomms127022041-1723https://doaj.org/article/b98f458b5e1746fcbf102e2496b3b6ec2016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12702https://doaj.org/toc/2041-1723Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca2+release from the endoplasmic reticulum.Wenbin ZhongQing YiBing XuShiqian LiTong WangFupei LiuBiying ZhuPeter R. HoffmannGuangju JiPingsheng LeiGuoping LiJiwei LiJian LiVesa M. OlkkonenDaoguang YanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wenbin Zhong Qing Yi Bing Xu Shiqian Li Tong Wang Fupei Liu Biying Zhu Peter R. Hoffmann Guangju Ji Pingsheng Lei Guoping Li Jiwei Li Jian Li Vesa M. Olkkonen Daoguang Yan ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
description	Lymphocytic leukaemia cells are characterized by high respiratory rates. Here, the authors report that the oxysterol-binding protein ORPL4 sustains mitochondrial respiration in T-cell acute lymphoblastic leukaemia cells by regulating Ca2+release from the endoplasmic reticulum.
format	article
author	Wenbin Zhong Qing Yi Bing Xu Shiqian Li Tong Wang Fupei Liu Biying Zhu Peter R. Hoffmann Guangju Ji Pingsheng Lei Guoping Li Jiwei Li Jian Li Vesa M. Olkkonen Daoguang Yan
author_facet	Wenbin Zhong Qing Yi Bing Xu Shiqian Li Tong Wang Fupei Liu Biying Zhu Peter R. Hoffmann Guangju Ji Pingsheng Lei Guoping Li Jiwei Li Jian Li Vesa M. Olkkonen Daoguang Yan
author_sort	Wenbin Zhong
title	ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
title_short	ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
title_full	ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
title_fullStr	ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
title_full_unstemmed	ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
title_sort	orp4l is essential for t-cell acute lymphoblastic leukemia cell survival
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b98f458b5e1746fcbf102e2496b3b6ec
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ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

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