Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats

Bone loss leading to osteopenia and osteoporosis is a frequent secondary complication of diabetes. This study aimed to evaluate the value of a traditionally used ‘anti-diabetic’ polyherbal mixture as a possible remedy for the prevention of this complication. Diabetes was induced in Wistar female rat...

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Autores principales:	Petrović Aleksandra, Madić Višnja, Jušković Marina, Đorđević Ljubiša, Vasiljević Perica
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	diabetes osteoprotective polyherbal mixture traditional medicine Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b990fec0bd72488e87daa3d5832e1e63
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spelling	oai:doaj.org-article:b990fec0bd72488e87daa3d5832e1e632021-11-17T21:27:54ZOsteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats1820-744810.2478/acve-2021-0023https://doaj.org/article/b990fec0bd72488e87daa3d5832e1e632021-09-01T00:00:00Zhttps://doi.org/10.2478/acve-2021-0023https://doaj.org/toc/1820-7448Bone loss leading to osteopenia and osteoporosis is a frequent secondary complication of diabetes. This study aimed to evaluate the value of a traditionally used ‘anti-diabetic’ polyherbal mixture as a possible remedy for the prevention of this complication. Diabetes was induced in Wistar female rats with a single intraperitoneal injection of alloxan monohydrate. The animals with blood glucose higher than 20 mmol/L for 14 consecutive days were considered diabetic. For the next 14 days, animals were treated with two concentrations of the polyherbal mixture (10 and 20 g of dry plant material/ kg). Bone histopathology was evaluated using the H&E and Masson’s trichrome staining. Alloxan-induced diabetes triggered bone histological changes characteristic for the development of osteopenia and osteoporosis and treatment with the polyherbal decoction restored these histopathological changes of the bones to the healthy animal level. At the same time, treatment with these tested doses has shown no adverse effects. These findings suggest that this mixture might be used as a remedy for the prevention of diabetic bone loss.Petrović AleksandraMadić VišnjaJušković MarinaĐorđević LjubišaVasiljević PericaSciendoarticlediabetesosteoprotectivepolyherbal mixturetraditional medicineVeterinary medicineSF600-1100ENActa Veterinaria, Vol 71, Iss 3, Pp 256-272 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes osteoprotective polyherbal mixture traditional medicine Veterinary medicine SF600-1100
spellingShingle	diabetes osteoprotective polyherbal mixture traditional medicine Veterinary medicine SF600-1100 Petrović Aleksandra Madić Višnja Jušković Marina Đorđević Ljubiša Vasiljević Perica Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
description	Bone loss leading to osteopenia and osteoporosis is a frequent secondary complication of diabetes. This study aimed to evaluate the value of a traditionally used ‘anti-diabetic’ polyherbal mixture as a possible remedy for the prevention of this complication. Diabetes was induced in Wistar female rats with a single intraperitoneal injection of alloxan monohydrate. The animals with blood glucose higher than 20 mmol/L for 14 consecutive days were considered diabetic. For the next 14 days, animals were treated with two concentrations of the polyherbal mixture (10 and 20 g of dry plant material/ kg). Bone histopathology was evaluated using the H&E and Masson’s trichrome staining. Alloxan-induced diabetes triggered bone histological changes characteristic for the development of osteopenia and osteoporosis and treatment with the polyherbal decoction restored these histopathological changes of the bones to the healthy animal level. At the same time, treatment with these tested doses has shown no adverse effects. These findings suggest that this mixture might be used as a remedy for the prevention of diabetic bone loss.
format	article
author	Petrović Aleksandra Madić Višnja Jušković Marina Đorđević Ljubiša Vasiljević Perica
author_facet	Petrović Aleksandra Madić Višnja Jušković Marina Đorđević Ljubiša Vasiljević Perica
author_sort	Petrović Aleksandra
title	Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
title_short	Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
title_full	Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
title_fullStr	Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
title_full_unstemmed	Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats
title_sort	osteoprotective effects of ‘anti-diabetic’ polyherbal mixture in type 1 diabetic rats
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/b990fec0bd72488e87daa3d5832e1e63
work_keys_str_mv	AT petrovicaleksandra osteoprotectiveeffectsofantidiabeticpolyherbalmixtureintype1diabeticrats AT madicvisnja osteoprotectiveeffectsofantidiabeticpolyherbalmixtureintype1diabeticrats AT juskovicmarina osteoprotectiveeffectsofantidiabeticpolyherbalmixtureintype1diabeticrats AT đorđevicljubisa osteoprotectiveeffectsofantidiabeticpolyherbalmixtureintype1diabeticrats AT vasiljevicperica osteoprotectiveeffectsofantidiabeticpolyherbalmixtureintype1diabeticrats
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Osteoprotective Effects of ‘Anti-Diabetic’ Polyherbal Mixture in Type 1 Diabetic Rats

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