Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block

Chronic wound repair is a common complication in patients with diabetes mellitus, which causes a heavy burden on social medical resources and the economy. Hypaphorine (HYP) has good anti-inflammatory effect, and chitosan (CS) is used in the treatment of wounds because of its good antibacterial effec...

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Autores principales:	Mengting Qi, Xuerui Zhu, Xiaoyi Yu, Min Ai, Weiwei Cai, Bin Du, Bao Hou, Liying Qiu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	HYP-NPS chronic wound IL-1β TNF-α inflammation Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b99891c445db485a89a0259e976e0afe
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spelling	oai:doaj.org-article:b99891c445db485a89a0259e976e0afe2021-11-25T18:30:08ZPreparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block10.3390/nano111128302079-4991https://doaj.org/article/b99891c445db485a89a0259e976e0afe2021-10-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2830https://doaj.org/toc/2079-4991Chronic wound repair is a common complication in patients with diabetes mellitus, which causes a heavy burden on social medical resources and the economy. Hypaphorine (HYP) has good anti-inflammatory effect, and chitosan (CS) is used in the treatment of wounds because of its good antibacterial effect. The purpose of this research was to investigate the role and mechanism of HYP-nano-microspheres in the treatment of wounds for diabetic rats. The morphology of HYP-NPS was observed by transmission electron microscopy (TEM). RAW 264.7 macrophages were used to assess the bio-compatibility of HYP-NPS. A full-thickness dermal wound in a diabetic rat model was performed to evaluate the wound healing function of HYP-NPS. The results revealed that HYP-NPS nanoparticles were spherical with an average diameter of approximately 50 nm. The cell experiments hinted that HYP-NPS had the potential as a trauma material. The wound test in diabetic rats indicated that HYP-NPS fostered the healing of chronic wounds. The mechanism was through down-regulating the expression of pro-inflammatory cytokines IL-1β and TNF-α in the skin of the wound, and accelerating the transition of chronic wound from inflammation to tissue regeneration. These results indicate that HYP-NPS has a good application prospect in the treatment of chronic wounds.Mengting QiXuerui ZhuXiaoyi YuMin AiWeiwei CaiBin DuBao HouLiying QiuMDPI AGarticleHYP-NPSchronic woundIL-1βTNF-αinflammationChemistryQD1-999ENNanomaterials, Vol 11, Iss 2830, p 2830 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HYP-NPS chronic wound IL-1β TNF-α inflammation Chemistry QD1-999
spellingShingle	HYP-NPS chronic wound IL-1β TNF-α inflammation Chemistry QD1-999 Mengting Qi Xuerui Zhu Xiaoyi Yu Min Ai Weiwei Cai Bin Du Bao Hou Liying Qiu Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
description	Chronic wound repair is a common complication in patients with diabetes mellitus, which causes a heavy burden on social medical resources and the economy. Hypaphorine (HYP) has good anti-inflammatory effect, and chitosan (CS) is used in the treatment of wounds because of its good antibacterial effect. The purpose of this research was to investigate the role and mechanism of HYP-nano-microspheres in the treatment of wounds for diabetic rats. The morphology of HYP-NPS was observed by transmission electron microscopy (TEM). RAW 264.7 macrophages were used to assess the bio-compatibility of HYP-NPS. A full-thickness dermal wound in a diabetic rat model was performed to evaluate the wound healing function of HYP-NPS. The results revealed that HYP-NPS nanoparticles were spherical with an average diameter of approximately 50 nm. The cell experiments hinted that HYP-NPS had the potential as a trauma material. The wound test in diabetic rats indicated that HYP-NPS fostered the healing of chronic wounds. The mechanism was through down-regulating the expression of pro-inflammatory cytokines IL-1β and TNF-α in the skin of the wound, and accelerating the transition of chronic wound from inflammation to tissue regeneration. These results indicate that HYP-NPS has a good application prospect in the treatment of chronic wounds.
format	article
author	Mengting Qi Xuerui Zhu Xiaoyi Yu Min Ai Weiwei Cai Bin Du Bao Hou Liying Qiu
author_facet	Mengting Qi Xuerui Zhu Xiaoyi Yu Min Ai Weiwei Cai Bin Du Bao Hou Liying Qiu
author_sort	Mengting Qi
title	Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
title_short	Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
title_full	Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
title_fullStr	Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
title_full_unstemmed	Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block
title_sort	preparation of w/o hypaphorine–chitosan nanoparticles and its application on promoting chronic wound healing via alleviating inflammation block
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b99891c445db485a89a0259e976e0afe
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Preparation of W/O Hypaphorine–Chitosan Nanoparticles and Its Application on Promoting Chronic Wound Healing via Alleviating Inflammation Block

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