Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line.

Metformin and sodium dichloroacetate effects on proliferation, apoptosis, and metabolic activity tested alone and in combination in a canine prostate and a bladder cancer cell line.

An important approach in tumor therapy is combining substances with different action mechanisms aiming to enhance the antineoplastic effect, decrease the therapeutic dosage, and avoid resistance mechanisms. Moreover, evaluating compounds already approved for the treatment of non-neoplastic diseases...

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Autores principales: Katharina Klose, Eva-Maria Packeiser, Petra Müller, José Luis Granados-Soler, Jan Torben Schille, Sandra Goericke-Pesch, Manfred Kietzmann, Hugo Murua Escobar, Ingo Nolte
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Medicine
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Science
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Acceso en línea:https://doaj.org/article/b9996766d02f4e898c1f803b5286a128
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