Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis

Abstract Limited data indicated radiotherapy might provide survival benefits to patients with distantly metastatic nasopharyngeal carcinoma (mNPC). We used the Surveillance Epidemiology and End Results database to examine the role of radiotherapy in the treatment of mNPC. Patients with mNPC at prese...

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Autores principales:	Jiyi Hu, Lin Kong, Jing Gao, Weixu Hu, Xiyin Guan, Jiade J. Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b99af01a28ce42f0886af947da3c4477
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spelling	oai:doaj.org-article:b99af01a28ce42f0886af947da3c44772021-12-02T11:40:51ZUse of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis10.1038/s41598-017-00655-12045-2322https://doaj.org/article/b99af01a28ce42f0886af947da3c44772017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00655-1https://doaj.org/toc/2045-2322Abstract Limited data indicated radiotherapy might provide survival benefits to patients with distantly metastatic nasopharyngeal carcinoma (mNPC). We used the Surveillance Epidemiology and End Results database to examine the role of radiotherapy in the treatment of mNPC. Patients with mNPC at presentation diagnosed between 1988 and 2012 were enrolled. The outcome of interest included overall survival (OS) and cancer-specific survival (CSS). A total of 679 patients with a median follow-up of 13 months were identified. Four hundred forty-eight patients received radiotherapy and 231 did not. Radiotherapy was associated with significantly improved OS and CSS in both univariate and multivariate analyses. Weighted Cox regression by inverse probability of treatment weighting (IPTW) using propensity score (PS) showed a 50% reduced risk of mortality in patients who received radiotherapy with regards to both OS (HR: 0.50, 95% CI: 0.41–0.60, p < 0.001) and CSS (HR: 0.50, 95% CI: 0.40–0.61, p < 0.001), respectively. Further, patients with a younger age (<65 year-old), diagnosed after 2003, with non-keratinizing carcinoma or undifferentiated carcinoma, and who received surgery had better outcomes for both OS and CSS. Local radiotherapy was associated with improved survival in patients with mNPC. Our findings warrant prospective investigation in clinical trials.Jiyi HuLin KongJing GaoWeixu HuXiyin GuanJiade J. LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jiyi Hu Lin Kong Jing Gao Weixu Hu Xiyin Guan Jiade J. Lu Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
description	Abstract Limited data indicated radiotherapy might provide survival benefits to patients with distantly metastatic nasopharyngeal carcinoma (mNPC). We used the Surveillance Epidemiology and End Results database to examine the role of radiotherapy in the treatment of mNPC. Patients with mNPC at presentation diagnosed between 1988 and 2012 were enrolled. The outcome of interest included overall survival (OS) and cancer-specific survival (CSS). A total of 679 patients with a median follow-up of 13 months were identified. Four hundred forty-eight patients received radiotherapy and 231 did not. Radiotherapy was associated with significantly improved OS and CSS in both univariate and multivariate analyses. Weighted Cox regression by inverse probability of treatment weighting (IPTW) using propensity score (PS) showed a 50% reduced risk of mortality in patients who received radiotherapy with regards to both OS (HR: 0.50, 95% CI: 0.41–0.60, p < 0.001) and CSS (HR: 0.50, 95% CI: 0.40–0.61, p < 0.001), respectively. Further, patients with a younger age (<65 year-old), diagnosed after 2003, with non-keratinizing carcinoma or undifferentiated carcinoma, and who received surgery had better outcomes for both OS and CSS. Local radiotherapy was associated with improved survival in patients with mNPC. Our findings warrant prospective investigation in clinical trials.
format	article
author	Jiyi Hu Lin Kong Jing Gao Weixu Hu Xiyin Guan Jiade J. Lu
author_facet	Jiyi Hu Lin Kong Jing Gao Weixu Hu Xiyin Guan Jiade J. Lu
author_sort	Jiyi Hu
title	Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
title_short	Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
title_full	Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
title_fullStr	Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
title_full_unstemmed	Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis
title_sort	use of radiation therapy in metastatic nasopharyngeal cancer improves survival: a seer analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b99af01a28ce42f0886af947da3c4477
work_keys_str_mv	AT jiyihu useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis AT linkong useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis AT jinggao useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis AT weixuhu useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis AT xiyinguan useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis AT jiadejlu useofradiationtherapyinmetastaticnasopharyngealcancerimprovessurvivalaseeranalysis
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Use of Radiation Therapy in Metastatic Nasopharyngeal Cancer Improves Survival: A SEER Analysis

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