Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion

Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine its structure and show that it phosphorylates the RO...

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Autores principales:	Gaëlle Lentini, Rouaa Ben Chaabene, Oscar Vadas, Chandra Ramakrishnan, Budhaditya Mukherjee, Ved Mehta, Matteo Lunghi, Jonas Grossmann, Bohumil Maco, Rémy Visentin, Adrian B. Hehl, Volodymyr M. Korkhov, Dominique Soldati-Favre
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b99ddeb7c5ca4acfb20ea9d41fb9e96c
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spelling	oai:doaj.org-article:b99ddeb7c5ca4acfb20ea9d41fb9e96c2021-12-02T17:23:48ZStructural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion10.1038/s41467-021-24083-y2041-1723https://doaj.org/article/b99ddeb7c5ca4acfb20ea9d41fb9e96c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24083-yhttps://doaj.org/toc/2041-1723Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine its structure and show that it phosphorylates the RON complex.Gaëlle LentiniRouaa Ben ChaabeneOscar VadasChandra RamakrishnanBudhaditya MukherjeeVed MehtaMatteo LunghiJonas GrossmannBohumil MacoRémy VisentinAdrian B. HehlVolodymyr M. KorkhovDominique Soldati-FavreNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gaëlle Lentini Rouaa Ben Chaabene Oscar Vadas Chandra Ramakrishnan Budhaditya Mukherjee Ved Mehta Matteo Lunghi Jonas Grossmann Bohumil Maco Rémy Visentin Adrian B. Hehl Volodymyr M. Korkhov Dominique Soldati-Favre Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
description	Host cell invasion by Toxoplasma gondii depends on the heavily phosphorylated RON complex, but the relevance and regulation of these modifications are not understood. Here, the authors identify the kinase RON13 as a key virulence factor, determine its structure and show that it phosphorylates the RON complex.
format	article
author	Gaëlle Lentini Rouaa Ben Chaabene Oscar Vadas Chandra Ramakrishnan Budhaditya Mukherjee Ved Mehta Matteo Lunghi Jonas Grossmann Bohumil Maco Rémy Visentin Adrian B. Hehl Volodymyr M. Korkhov Dominique Soldati-Favre
author_facet	Gaëlle Lentini Rouaa Ben Chaabene Oscar Vadas Chandra Ramakrishnan Budhaditya Mukherjee Ved Mehta Matteo Lunghi Jonas Grossmann Bohumil Maco Rémy Visentin Adrian B. Hehl Volodymyr M. Korkhov Dominique Soldati-Favre
author_sort	Gaëlle Lentini
title	Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
title_short	Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
title_full	Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
title_fullStr	Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
title_full_unstemmed	Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion
title_sort	structural insights into an atypical secretory pathway kinase crucial for toxoplasma gondii invasion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b99ddeb7c5ca4acfb20ea9d41fb9e96c
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Structural insights into an atypical secretory pathway kinase crucial for Toxoplasma gondii invasion

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