Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh

Abstract Fatal human cases of avian-origin H10N8 influenza virus infections have raised concern about their potential for human-to-human transmission. H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic aquatic birds across Eurasia and North America. We isolated eigh...

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Autores principales:	Rabeh El-Shesheny, John Franks, Bindumadhav M. Marathe, M. Kamrul Hasan, Mohammed M. Feeroz, Scott Krauss, Peter Vogel, Pamela McKenzie, Richard J. Webby, Robert G. Webster
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b99f072de14643db8163681095b4cb88
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spelling	oai:doaj.org-article:b99f072de14643db8163681095b4cb882021-12-02T12:31:56ZGenetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh10.1038/s41598-018-29079-12045-2322https://doaj.org/article/b99f072de14643db8163681095b4cb882018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-29079-1https://doaj.org/toc/2045-2322Abstract Fatal human cases of avian-origin H10N8 influenza virus infections have raised concern about their potential for human-to-human transmission. H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic aquatic birds across Eurasia and North America. We isolated eight H10 AIVs (four H10N7, two H10N9, one H10N1, and one H10N6) from live poultry markets in Bangladesh. Genetic analyses demonstrated that all eight isolates belong to the Eurasian lineage. HA phylogenetic and antigenic analyses indicated that two antigenically distinct groups of H10 AIVs are circulating in Bangladeshi live poultry markets. We evaluated the virulence of four representative H10 AIV strains in DBA/2J mice and found that they replicated efficiently in mice without prior adaptation. Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination. These results indicate that H10 AIVs pose a potential threat to human health and the mechanisms of their transmissibility should be elucidated.Rabeh El-SheshenyJohn FranksBindumadhav M. MaratheM. Kamrul HasanMohammed M. FeerozScott KraussPeter VogelPamela McKenzieRichard J. WebbyRobert G. WebsterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rabeh El-Shesheny John Franks Bindumadhav M. Marathe M. Kamrul Hasan Mohammed M. Feeroz Scott Krauss Peter Vogel Pamela McKenzie Richard J. Webby Robert G. Webster Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
description	Abstract Fatal human cases of avian-origin H10N8 influenza virus infections have raised concern about their potential for human-to-human transmission. H10 subtype avian influenza viruses (AIVs) have been isolated from wild and domestic aquatic birds across Eurasia and North America. We isolated eight H10 AIVs (four H10N7, two H10N9, one H10N1, and one H10N6) from live poultry markets in Bangladesh. Genetic analyses demonstrated that all eight isolates belong to the Eurasian lineage. HA phylogenetic and antigenic analyses indicated that two antigenically distinct groups of H10 AIVs are circulating in Bangladeshi live poultry markets. We evaluated the virulence of four representative H10 AIV strains in DBA/2J mice and found that they replicated efficiently in mice without prior adaptation. Moreover, H10N6 and H10N1 AIVs caused high mortality with systemic dissemination. These results indicate that H10 AIVs pose a potential threat to human health and the mechanisms of their transmissibility should be elucidated.
format	article
author	Rabeh El-Shesheny John Franks Bindumadhav M. Marathe M. Kamrul Hasan Mohammed M. Feeroz Scott Krauss Peter Vogel Pamela McKenzie Richard J. Webby Robert G. Webster
author_facet	Rabeh El-Shesheny John Franks Bindumadhav M. Marathe M. Kamrul Hasan Mohammed M. Feeroz Scott Krauss Peter Vogel Pamela McKenzie Richard J. Webby Robert G. Webster
author_sort	Rabeh El-Shesheny
title	Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
title_short	Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
title_full	Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
title_fullStr	Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
title_full_unstemmed	Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh
title_sort	genetic characterization and pathogenic potential of h10 avian influenza viruses isolated from live poultry markets in bangladesh
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b99f072de14643db8163681095b4cb88
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Genetic characterization and pathogenic potential of H10 avian influenza viruses isolated from live poultry markets in Bangladesh

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