The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis

Sinha and Winther show that the Escherichia coli RelA inactive hydrolase domain modulates the activity of the synthetase domain. RelA produces (p)ppGpp in γ-proteobacteria; using mutagenesis screening and functional studies, the authors demonstrate that the H loop region in the RelA hydrolase domain...

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Autores principales:	Anurag Kumar Sinha, Kristoffer Skovbo Winther
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b99f573a4a374f47ae0a1c69ab137e36
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spelling	oai:doaj.org-article:b99f573a4a374f47ae0a1c69ab137e362021-12-02T13:27:04ZThe RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis10.1038/s42003-021-01963-z2399-3642https://doaj.org/article/b99f573a4a374f47ae0a1c69ab137e362021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01963-zhttps://doaj.org/toc/2399-3642Sinha and Winther show that the Escherichia coli RelA inactive hydrolase domain modulates the activity of the synthetase domain. RelA produces (p)ppGpp in γ-proteobacteria; using mutagenesis screening and functional studies, the authors demonstrate that the H loop region in the RelA hydrolase domain acts as a molecular switch to regulate the synthetase domain activity of the enzyme.Anurag Kumar SinhaKristoffer Skovbo WintherNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Anurag Kumar Sinha Kristoffer Skovbo Winther The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
description	Sinha and Winther show that the Escherichia coli RelA inactive hydrolase domain modulates the activity of the synthetase domain. RelA produces (p)ppGpp in γ-proteobacteria; using mutagenesis screening and functional studies, the authors demonstrate that the H loop region in the RelA hydrolase domain acts as a molecular switch to regulate the synthetase domain activity of the enzyme.
format	article
author	Anurag Kumar Sinha Kristoffer Skovbo Winther
author_facet	Anurag Kumar Sinha Kristoffer Skovbo Winther
author_sort	Anurag Kumar Sinha
title	The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
title_short	The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
title_full	The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
title_fullStr	The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
title_full_unstemmed	The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis
title_sort	rela hydrolase domain acts as a molecular switch for (p)ppgpp synthesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b99f573a4a374f47ae0a1c69ab137e36
work_keys_str_mv	AT anuragkumarsinha therelahydrolasedomainactsasamolecularswitchforpppgppsynthesis AT kristofferskovbowinther therelahydrolasedomainactsasamolecularswitchforpppgppsynthesis AT anuragkumarsinha relahydrolasedomainactsasamolecularswitchforpppgppsynthesis AT kristofferskovbowinther relahydrolasedomainactsasamolecularswitchforpppgppsynthesis
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The RelA hydrolase domain acts as a molecular switch for (p)ppGpp synthesis

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