Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

Genetic heterogeneity in breast cancer has been demonstrated at a single-cell resolution with high levels of genome coverage. Here, the authors perform transcriptome analysis of 515 single cells from 11 patients and define core gene expression signatures for subtype-specific single breast cancer cel...

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Autores principales:	Woosung Chung, Hye Hyeon Eum, Hae-Ock Lee, Kyung-Min Lee, Han-Byoel Lee, Kyu-Tae Kim, Han Suk Ryu, Sangmin Kim, Jeong Eon Lee, Yeon Hee Park, Zhengyan Kan, Wonshik Han, Woong-Yang Park
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9a81dca4e5b4202ba19ac7f9d8afdd3
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spelling	oai:doaj.org-article:b9a81dca4e5b4202ba19ac7f9d8afdd32021-12-02T15:38:53ZSingle-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer10.1038/ncomms150812041-1723https://doaj.org/article/b9a81dca4e5b4202ba19ac7f9d8afdd32017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15081https://doaj.org/toc/2041-1723Genetic heterogeneity in breast cancer has been demonstrated at a single-cell resolution with high levels of genome coverage. Here, the authors perform transcriptome analysis of 515 single cells from 11 patients and define core gene expression signatures for subtype-specific single breast cancer cells and tumour-infiltrating immune cells.Woosung ChungHye Hyeon EumHae-Ock LeeKyung-Min LeeHan-Byoel LeeKyu-Tae KimHan Suk RyuSangmin KimJeong Eon LeeYeon Hee ParkZhengyan KanWonshik HanWoong-Yang ParkNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Woosung Chung Hye Hyeon Eum Hae-Ock Lee Kyung-Min Lee Han-Byoel Lee Kyu-Tae Kim Han Suk Ryu Sangmin Kim Jeong Eon Lee Yeon Hee Park Zhengyan Kan Wonshik Han Woong-Yang Park Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
description	Genetic heterogeneity in breast cancer has been demonstrated at a single-cell resolution with high levels of genome coverage. Here, the authors perform transcriptome analysis of 515 single cells from 11 patients and define core gene expression signatures for subtype-specific single breast cancer cells and tumour-infiltrating immune cells.
format	article
author	Woosung Chung Hye Hyeon Eum Hae-Ock Lee Kyung-Min Lee Han-Byoel Lee Kyu-Tae Kim Han Suk Ryu Sangmin Kim Jeong Eon Lee Yeon Hee Park Zhengyan Kan Wonshik Han Woong-Yang Park
author_facet	Woosung Chung Hye Hyeon Eum Hae-Ock Lee Kyung-Min Lee Han-Byoel Lee Kyu-Tae Kim Han Suk Ryu Sangmin Kim Jeong Eon Lee Yeon Hee Park Zhengyan Kan Wonshik Han Woong-Yang Park
author_sort	Woosung Chung
title	Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
title_short	Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
title_full	Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
title_fullStr	Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
title_full_unstemmed	Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
title_sort	single-cell rna-seq enables comprehensive tumour and immune cell profiling in primary breast cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b9a81dca4e5b4202ba19ac7f9d8afdd3
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Single-cell RNA-seq enables comprehensive tumour and immune cell profiling in primary breast cancer

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