Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy

Abstract Delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Susana Merino-Caviedes, Lilian K. Gutierrez, José Manuel Alfonso-Almazán, Santiago Sanz-Estébanez, Lucilio Cordero-Grande, Jorge G. Quintanilla, Javier Sánchez-González, Manuel Marina-Breysse, Carlos Galán-Arriola, Daniel Enríquez-Vázquez, Carlos Torres, Gonzalo Pizarro, Borja Ibáñez, Rafael Peinado, Jose Luis Merino, Julián Pérez-Villacastín, José Jalife, Mariña López-Yunta, Mariano Vázquez, Jazmín Aguado-Sierra, Juan José González-Ferrer, Nicasio Pérez-Castellano, Marcos Martín-Fernández, Carlos Alberola-López, David Filgueiras-Rama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9a82806281249e68ab196a410e36d84
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b9a82806281249e68ab196a410e36d84
record_format	dspace
spelling	oai:doaj.org-article:b9a82806281249e68ab196a410e36d842021-12-02T17:37:23ZTime-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy10.1038/s41598-021-97399-w2045-2322https://doaj.org/article/b9a82806281249e68ab196a410e36d842021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97399-whttps://doaj.org/toc/2045-2322Abstract Delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.Susana Merino-CaviedesLilian K. GutierrezJosé Manuel Alfonso-AlmazánSantiago Sanz-EstébanezLucilio Cordero-GrandeJorge G. QuintanillaJavier Sánchez-GonzálezManuel Marina-BreysseCarlos Galán-ArriolaDaniel Enríquez-VázquezCarlos TorresGonzalo PizarroBorja IbáñezRafael PeinadoJose Luis MerinoJulián Pérez-VillacastínJosé JalifeMariña López-YuntaMariano VázquezJazmín Aguado-SierraJuan José González-FerrerNicasio Pérez-CastellanoMarcos Martín-FernándezCarlos Alberola-LópezDavid Filgueiras-RamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Susana Merino-Caviedes Lilian K. Gutierrez José Manuel Alfonso-Almazán Santiago Sanz-Estébanez Lucilio Cordero-Grande Jorge G. Quintanilla Javier Sánchez-González Manuel Marina-Breysse Carlos Galán-Arriola Daniel Enríquez-Vázquez Carlos Torres Gonzalo Pizarro Borja Ibáñez Rafael Peinado Jose Luis Merino Julián Pérez-Villacastín José Jalife Mariña López-Yunta Mariano Vázquez Jazmín Aguado-Sierra Juan José González-Ferrer Nicasio Pérez-Castellano Marcos Martín-Fernández Carlos Alberola-López David Filgueiras-Rama Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
description	Abstract Delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging requires novel and time-efficient approaches to characterize the myocardial substrate associated with ventricular arrhythmia in patients with ischemic cardiomyopathy. Using a translational approach in pigs and patients with established myocardial infarction, we tested and validated a novel 3D methodology to assess ventricular scar using custom transmural criteria and a semiautomatic approach to obtain transmural scar maps in ventricular models reconstructed from both 3D-acquired and 3D-upsampled-2D-acquired LGE-CMR images. The results showed that 3D-upsampled models from 2D LGE-CMR images provided a time-efficient alternative to 3D-acquired sequences to assess the myocardial substrate associated with ischemic cardiomyopathy. Scar assessment from 2D-LGE-CMR sequences using 3D-upsampled models was superior to conventional 2D assessment to identify scar sizes associated with the cycle length of spontaneous ventricular tachycardia episodes and long-term ventricular tachycardia recurrences after catheter ablation. This novel methodology may represent an efficient approach in clinical practice after manual or automatic segmentation of myocardial borders in a small number of conventional 2D LGE-CMR slices and automatic scar detection.
format	article
author	Susana Merino-Caviedes Lilian K. Gutierrez José Manuel Alfonso-Almazán Santiago Sanz-Estébanez Lucilio Cordero-Grande Jorge G. Quintanilla Javier Sánchez-González Manuel Marina-Breysse Carlos Galán-Arriola Daniel Enríquez-Vázquez Carlos Torres Gonzalo Pizarro Borja Ibáñez Rafael Peinado Jose Luis Merino Julián Pérez-Villacastín José Jalife Mariña López-Yunta Mariano Vázquez Jazmín Aguado-Sierra Juan José González-Ferrer Nicasio Pérez-Castellano Marcos Martín-Fernández Carlos Alberola-López David Filgueiras-Rama
author_facet	Susana Merino-Caviedes Lilian K. Gutierrez José Manuel Alfonso-Almazán Santiago Sanz-Estébanez Lucilio Cordero-Grande Jorge G. Quintanilla Javier Sánchez-González Manuel Marina-Breysse Carlos Galán-Arriola Daniel Enríquez-Vázquez Carlos Torres Gonzalo Pizarro Borja Ibáñez Rafael Peinado Jose Luis Merino Julián Pérez-Villacastín José Jalife Mariña López-Yunta Mariano Vázquez Jazmín Aguado-Sierra Juan José González-Ferrer Nicasio Pérez-Castellano Marcos Martín-Fernández Carlos Alberola-López David Filgueiras-Rama
author_sort	Susana Merino-Caviedes
title	Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
title_short	Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
title_full	Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
title_fullStr	Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
title_full_unstemmed	Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
title_sort	time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9a82806281249e68ab196a410e36d84
work_keys_str_mv	AT susanamerinocaviedes timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT liliankgutierrez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT josemanuelalfonsoalmazan timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT santiagosanzestebanez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT luciliocorderogrande timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT jorgegquintanilla timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT javiersanchezgonzalez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT manuelmarinabreysse timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT carlosgalanarriola timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT danielenriquezvazquez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT carlostorres timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT gonzalopizarro timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT borjaibanez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT rafaelpeinado timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT joseluismerino timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT julianperezvillacastin timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT josejalife timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT marinalopezyunta timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT marianovazquez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT jazminaguadosierra timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT juanjosegonzalezferrer timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT nicasioperezcastellano timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT marcosmartinfernandez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT carlosalberolalopez timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy AT davidfilgueirasrama timeefficientthreedimensionaltransmuralscarassessmentprovidesrelevantsubstratecharacterizationforventriculartachycardiafeaturesandlongtermrecurrencesinischemiccardiomyopathy
_version_	1718379905507393536

Time-efficient three-dimensional transmural scar assessment provides relevant substrate characterization for ventricular tachycardia features and long-term recurrences in ischemic cardiomyopathy

Ejemplares similares