Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41

In the present study, nanoporous material type MCM-41 was prepared by the sol-gel technique and was used as a carrier for prednisolone (PRD) drug delivery. The structural properties of mesoporous were fully characterized by X-ray diffraction (XRD), N2 adsorption /desorption and Fourier-transform in...

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Autores principales:	Talib M. Albayati, Abd Alkadir A. Jassam
Formato:	article
Lenguaje:	EN
Publicado:	Al-Khwarizmi College of Engineering – University of Baghdad 2019
Materias:	Drug delivery, Kinetics model, MCM-41, Prednisolone. Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040
Acceso en línea:	https://doaj.org/article/b9a903f2db2642028a49307b9ed09358
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spelling	oai:doaj.org-article:b9a903f2db2642028a49307b9ed093582021-12-02T03:50:43ZExperimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-411818-11712312-0789https://doaj.org/article/b9a903f2db2642028a49307b9ed093582019-03-01T00:00:00Zhttp://alkej.uobaghdad.edu.iq/index.php/alkej/article/view/426https://doaj.org/toc/1818-1171https://doaj.org/toc/2312-0789 In the present study, nanoporous material type MCM-41 was prepared by the sol-gel technique and was used as a carrier for prednisolone (PRD) drug delivery. The structural properties of mesoporous were fully characterized by X-ray diffraction (XRD), N2 adsorption /desorption and Fourier-transform infrared (FTIR). The mass transfer in term of adsorption process (loading) and desorption process (releasing) properties were investigated. The maximum drug loading efficiency was equal to 38% and 47.5% at different concentrations. The PRD released was prudently studied in water media of pH 6.8 simulated body fluid (SBF) in according to "United State Pharmacopeia (USP38)". The results proved that the release of prednisolone from MCM-41 was (69.4%) after 24 hr. The data of the released PRD was found to be submitted to a Korsmeyer–Peppas model. Talib M. AlbayatiAbd Alkadir A. JassamAl-Khwarizmi College of Engineering – University of BaghdadarticleDrug delivery, Kinetics model, MCM-41, Prednisolone.Chemical engineeringTP155-156Engineering (General). Civil engineering (General)TA1-2040ENAl-Khawarizmi Engineering Journal, Vol 15, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Drug delivery, Kinetics model, MCM-41, Prednisolone. Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040
spellingShingle	Drug delivery, Kinetics model, MCM-41, Prednisolone. Chemical engineering TP155-156 Engineering (General). Civil engineering (General) TA1-2040 Talib M. Albayati Abd Alkadir A. Jassam Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
description	In the present study, nanoporous material type MCM-41 was prepared by the sol-gel technique and was used as a carrier for prednisolone (PRD) drug delivery. The structural properties of mesoporous were fully characterized by X-ray diffraction (XRD), N2 adsorption /desorption and Fourier-transform infrared (FTIR). The mass transfer in term of adsorption process (loading) and desorption process (releasing) properties were investigated. The maximum drug loading efficiency was equal to 38% and 47.5% at different concentrations. The PRD released was prudently studied in water media of pH 6.8 simulated body fluid (SBF) in according to "United State Pharmacopeia (USP38)". The results proved that the release of prednisolone from MCM-41 was (69.4%) after 24 hr. The data of the released PRD was found to be submitted to a Korsmeyer–Peppas model.
format	article
author	Talib M. Albayati Abd Alkadir A. Jassam
author_facet	Talib M. Albayati Abd Alkadir A. Jassam
author_sort	Talib M. Albayati
title	Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
title_short	Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
title_full	Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
title_fullStr	Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
title_full_unstemmed	Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41
title_sort	experimental study of drug delivery system for prednisolone loaded and released by mesoporous silica mcm-41
publisher	Al-Khwarizmi College of Engineering – University of Baghdad
publishDate	2019
url	https://doaj.org/article/b9a903f2db2642028a49307b9ed09358
work_keys_str_mv	AT talibmalbayati experimentalstudyofdrugdeliverysystemforprednisoloneloadedandreleasedbymesoporoussilicamcm41 AT abdalkadirajassam experimentalstudyofdrugdeliverysystemforprednisoloneloadedandreleasedbymesoporoussilicamcm41
_version_	1718401613574438912

Experimental Study of Drug Delivery system for Prednisolone Loaded and Released by Mesoporous Silica MCM-41

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