Sociobiological control of plasmid copy number in bacteria.

All genes critical for plasmid replication regulation are located on the plasmid rather than on the host chromosome. It is possible therefore that there can be copy-up "cheater" mutants. In spite of this possibility, low copy number plasmids appear to exist stably in host populations. We e...

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Autores principales:	Mukta M Watve, Neelesh Dahanukar, Milind G Watve
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9ad87c6605d43178148fff21734baab
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spelling	oai:doaj.org-article:b9ad87c6605d43178148fff21734baab2021-11-25T06:25:35ZSociobiological control of plasmid copy number in bacteria.1932-620310.1371/journal.pone.0009328https://doaj.org/article/b9ad87c6605d43178148fff21734baab2010-02-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20195362/?tool=EBIhttps://doaj.org/toc/1932-6203All genes critical for plasmid replication regulation are located on the plasmid rather than on the host chromosome. It is possible therefore that there can be copy-up "cheater" mutants. In spite of this possibility, low copy number plasmids appear to exist stably in host populations. We examined this paradox using a multilevel selection model. Simulations showed that, a slightly higher copy number mutant could out-compete the wild type. Consequently, another mutant with still higher copy number could invade the first invader. However, the realized benefit of increasing intra-host fitness was saturating whereas that of inter-host fitness was exponential. As a result, above a threshold, intra-host selection was overcompensated by inter-host selection and the low copy number wild type plasmid could back invade a very high copy number plasmid. This led to a rock-paper-scissor (RPS) like situation that allowed the coexistence of plasmids with varied copy numbers. Furthermore, another type of cheater that had lost the genes required for conjugation but could hitchhike on a conjugal plasmid, could further reduce the advantage of copy-up mutants. These sociobiological interactions may compliment molecular mechanisms of replication regulation in stabilizing the copy numbers.Mukta M WatveNeelesh DahanukarMilind G WatvePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 2, p e9328 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mukta M Watve Neelesh Dahanukar Milind G Watve Sociobiological control of plasmid copy number in bacteria.
description	All genes critical for plasmid replication regulation are located on the plasmid rather than on the host chromosome. It is possible therefore that there can be copy-up "cheater" mutants. In spite of this possibility, low copy number plasmids appear to exist stably in host populations. We examined this paradox using a multilevel selection model. Simulations showed that, a slightly higher copy number mutant could out-compete the wild type. Consequently, another mutant with still higher copy number could invade the first invader. However, the realized benefit of increasing intra-host fitness was saturating whereas that of inter-host fitness was exponential. As a result, above a threshold, intra-host selection was overcompensated by inter-host selection and the low copy number wild type plasmid could back invade a very high copy number plasmid. This led to a rock-paper-scissor (RPS) like situation that allowed the coexistence of plasmids with varied copy numbers. Furthermore, another type of cheater that had lost the genes required for conjugation but could hitchhike on a conjugal plasmid, could further reduce the advantage of copy-up mutants. These sociobiological interactions may compliment molecular mechanisms of replication regulation in stabilizing the copy numbers.
format	article
author	Mukta M Watve Neelesh Dahanukar Milind G Watve
author_facet	Mukta M Watve Neelesh Dahanukar Milind G Watve
author_sort	Mukta M Watve
title	Sociobiological control of plasmid copy number in bacteria.
title_short	Sociobiological control of plasmid copy number in bacteria.
title_full	Sociobiological control of plasmid copy number in bacteria.
title_fullStr	Sociobiological control of plasmid copy number in bacteria.
title_full_unstemmed	Sociobiological control of plasmid copy number in bacteria.
title_sort	sociobiological control of plasmid copy number in bacteria.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/b9ad87c6605d43178148fff21734baab
work_keys_str_mv	AT muktamwatve sociobiologicalcontrolofplasmidcopynumberinbacteria AT neeleshdahanukar sociobiologicalcontrolofplasmidcopynumberinbacteria AT milindgwatve sociobiologicalcontrolofplasmidcopynumberinbacteria
_version_	1718413766703448064

Sociobiological control of plasmid copy number in bacteria.

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