Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs

Abstract Background The use of telmisartan (TEL), an angiotensin‐receptor blocker, for the control of systemic hypertension and proteinuria in dogs has not been reported extensively in a clinical setting. Objectives To determine the effects of an angiotensin‐converting enzyme inhibitor (ACEi) alone,...

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Autores principales:	Brittany L. Fowler, Darko Stefanovski, Rebecka S. Hess, Kathryn McGonigle
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	angiotensin receptor blocker hypertension protein losing nephropathy urine protein to creatinine ratio Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/b9af4db5f0cf46349157ba0cc4460dc8
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spelling	oai:doaj.org-article:b9af4db5f0cf46349157ba0cc4460dc82021-11-30T17:01:02ZEffect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs1939-16760891-664010.1111/jvim.16102https://doaj.org/article/b9af4db5f0cf46349157ba0cc4460dc82021-05-01T00:00:00Zhttps://doi.org/10.1111/jvim.16102https://doaj.org/toc/0891-6640https://doaj.org/toc/1939-1676Abstract Background The use of telmisartan (TEL), an angiotensin‐receptor blocker, for the control of systemic hypertension and proteinuria in dogs has not been reported extensively in a clinical setting. Objectives To determine the effects of an angiotensin‐converting enzyme inhibitor (ACEi) alone, ACEi in combination with TEL, or TEL alone on systolic blood pressure and proteinuria in dogs with protein losing nephropathy (PLN). Animals Forty‐two client‐owned dogs being treated for PLN. Methods Retrospective observational study of medical records of dogs at a university teaching hospital from 2012 to 2018 with the use of benazepril or enalapril alone, TEL alone, or both modalities for the management of PLN. Noninvasive blood pressure and urine protein to creatinine ratio (UPC) were compared among the treatment groups over time. A multivariable mixed‐effects linear regression model followed by post hoc analysis was used to estimate the marginal means and differences between the treatment groups. Results In comparison to group ACEi alone, combination treatment of an ACEi with TEL significantly reduced (P = .007) systolic blood pressure by 13 mm Hg (95% confidence interval [95% CI]: 4‐22 mm Hg). Angiotensin‐converting enzyme inhibitor + TEL in comparison to ACEi alone showed significant (P = .01) reduction in UPC of 2.5 (95% CI: 0.6‐4.4). The UPC of group ACEi + TEL was significantly lower (P = .01) in comparison to TEL alone by 3.8 (95% CI: 0.8‐6.8). Conclusions and Clinical Importance Telmisartan can be used to treat systemic hypertension and proteinuria in dogs.Brittany L. FowlerDarko StefanovskiRebecka S. HessKathryn McGonigleWileyarticleangiotensin receptor blockerhypertensionprotein losing nephropathyurine protein to creatinine ratioVeterinary medicineSF600-1100ENJournal of Veterinary Internal Medicine, Vol 35, Iss 3, Pp 1231-1237 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	angiotensin receptor blocker hypertension protein losing nephropathy urine protein to creatinine ratio Veterinary medicine SF600-1100
spellingShingle	angiotensin receptor blocker hypertension protein losing nephropathy urine protein to creatinine ratio Veterinary medicine SF600-1100 Brittany L. Fowler Darko Stefanovski Rebecka S. Hess Kathryn McGonigle Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
description	Abstract Background The use of telmisartan (TEL), an angiotensin‐receptor blocker, for the control of systemic hypertension and proteinuria in dogs has not been reported extensively in a clinical setting. Objectives To determine the effects of an angiotensin‐converting enzyme inhibitor (ACEi) alone, ACEi in combination with TEL, or TEL alone on systolic blood pressure and proteinuria in dogs with protein losing nephropathy (PLN). Animals Forty‐two client‐owned dogs being treated for PLN. Methods Retrospective observational study of medical records of dogs at a university teaching hospital from 2012 to 2018 with the use of benazepril or enalapril alone, TEL alone, or both modalities for the management of PLN. Noninvasive blood pressure and urine protein to creatinine ratio (UPC) were compared among the treatment groups over time. A multivariable mixed‐effects linear regression model followed by post hoc analysis was used to estimate the marginal means and differences between the treatment groups. Results In comparison to group ACEi alone, combination treatment of an ACEi with TEL significantly reduced (P = .007) systolic blood pressure by 13 mm Hg (95% confidence interval [95% CI]: 4‐22 mm Hg). Angiotensin‐converting enzyme inhibitor + TEL in comparison to ACEi alone showed significant (P = .01) reduction in UPC of 2.5 (95% CI: 0.6‐4.4). The UPC of group ACEi + TEL was significantly lower (P = .01) in comparison to TEL alone by 3.8 (95% CI: 0.8‐6.8). Conclusions and Clinical Importance Telmisartan can be used to treat systemic hypertension and proteinuria in dogs.
format	article
author	Brittany L. Fowler Darko Stefanovski Rebecka S. Hess Kathryn McGonigle
author_facet	Brittany L. Fowler Darko Stefanovski Rebecka S. Hess Kathryn McGonigle
author_sort	Brittany L. Fowler
title	Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
title_short	Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
title_full	Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
title_fullStr	Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
title_full_unstemmed	Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
title_sort	effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/b9af4db5f0cf46349157ba0cc4460dc8
work_keys_str_mv	AT brittanylfowler effectoftelmisartanangiotensinconvertingenzymeinhibitionorbothonproteinuriaandbloodpressureindogs AT darkostefanovski effectoftelmisartanangiotensinconvertingenzymeinhibitionorbothonproteinuriaandbloodpressureindogs AT rebeckashess effectoftelmisartanangiotensinconvertingenzymeinhibitionorbothonproteinuriaandbloodpressureindogs AT kathrynmcgonigle effectoftelmisartanangiotensinconvertingenzymeinhibitionorbothonproteinuriaandbloodpressureindogs
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Effect of telmisartan, angiotensin‐converting enzyme inhibition, or both, on proteinuria and blood pressure in dogs

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