Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G

Dimerization regulates both deaminase-dependent and deaminase-independent HIV-1 restriction by APOBEC3G

APOBEC3G inhibits HIV-1 viral replication via catalytic and non-catalytic processes. Here the authors show that APOBEC3G binds single-stranded DNA as an active deaminase monomer, subsequently forming catalytic-inactive dimers that block reverse transcriptase-mediated DNA synthesis.

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Autores principales: Michael Morse, Ran Huo, Yuqing Feng, Ioulia Rouzina, Linda Chelico, Mark C. Williams
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/b9af9a0b30144b59809406b814538401
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