EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES

Objective: To assess the effectiveness of sodium polystyrene sulphonate in treating hyperkalemia and its effect on different serum electrolytes level. Study Design: Quasi-experimental study. Place and Duration of Study: Lyari general hospital, 500 bedded tertiary care public sector hospital...

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Autores principales:	Azfar Athar Ishaqui, Masood Ahmed Khan, Adnan Iqbal, Syed Hameez Jawed, Farah Khalid, Mir Muhammad Uzairullah, Muhammad Talha, Usman Ashfaq, Najam Zehra
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	sodium polystyrene sulphonate hperkalemia Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9b082a6532f4c3cb2090f365eebc367
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spelling	oai:doaj.org-article:b9b082a6532f4c3cb2090f365eebc3672021-11-15T05:10:10ZEVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES0030-96482411-8842https://doaj.org/article/b9b082a6532f4c3cb2090f365eebc3672019-02-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2493/2048https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To assess the effectiveness of sodium polystyrene sulphonate in treating hyperkalemia and its effect on different serum electrolytes level. Study Design: Quasi-experimental study. Place and Duration of Study: Lyari general hospital, 500 bedded tertiary care public sector hospital at Karachi, from Jan 2017 to Mar 2017. Material and Methods: Hyperkalemic patients were included in study who fulfilled inclusion criteria and were administered with single STAT 30 grams dose of Sodium Polystyrene Sulfonate. Serum electrolytes such as sodium, chloride, magnesium, phosphate and calcium were measured before and after 2 hours of administration of Sodium Polystyrene Sulfonate. Paired t-test was used as tool for statistical analysis. Results: Significant (p<0.05) decrease in serum potassium level with mean decrease of 0.61 mmol/L was observed in hyperkalemic patients (n=83) after single dose of Sodium Polystyrene Sulfonate. Among 83 studied patient, 67 (81%) recovered from hyperkalemia. Besides, there was significant (p<0.05) increase in sodium level with a mean increase of 2.26 mmol/L. Serum magnesium and calcium levels were significantly decreased (p<0.05) with mean difference of 0.02mmol/L and 0.13mmol/L respectively. No significant difference was found in serum chloride and phosphate levels (p>0.05). Conclusion: Sodium polystyrene sulphonate found to be effective in treating hyperkalemia and considerable changes in serum sodium level have been observed with minimal changes in serum magnesium and calcium levels.Azfar Athar IshaquiMasood Ahmed KhanAdnan IqbalSyed Hameez JawedFarah KhalidMir Muhammad UzairullahMuhammad TalhaUsman AshfaqNajam ZehraArmy Medical College Rawalpindiarticlesodium polystyrene sulphonatehperkalemiaMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 1, Pp 37-42 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	sodium polystyrene sulphonate hperkalemia Medicine R Medicine (General) R5-920
spellingShingle	sodium polystyrene sulphonate hperkalemia Medicine R Medicine (General) R5-920 Azfar Athar Ishaqui Masood Ahmed Khan Adnan Iqbal Syed Hameez Jawed Farah Khalid Mir Muhammad Uzairullah Muhammad Talha Usman Ashfaq Najam Zehra EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
description	Objective: To assess the effectiveness of sodium polystyrene sulphonate in treating hyperkalemia and its effect on different serum electrolytes level. Study Design: Quasi-experimental study. Place and Duration of Study: Lyari general hospital, 500 bedded tertiary care public sector hospital at Karachi, from Jan 2017 to Mar 2017. Material and Methods: Hyperkalemic patients were included in study who fulfilled inclusion criteria and were administered with single STAT 30 grams dose of Sodium Polystyrene Sulfonate. Serum electrolytes such as sodium, chloride, magnesium, phosphate and calcium were measured before and after 2 hours of administration of Sodium Polystyrene Sulfonate. Paired t-test was used as tool for statistical analysis. Results: Significant (p<0.05) decrease in serum potassium level with mean decrease of 0.61 mmol/L was observed in hyperkalemic patients (n=83) after single dose of Sodium Polystyrene Sulfonate. Among 83 studied patient, 67 (81%) recovered from hyperkalemia. Besides, there was significant (p<0.05) increase in sodium level with a mean increase of 2.26 mmol/L. Serum magnesium and calcium levels were significantly decreased (p<0.05) with mean difference of 0.02mmol/L and 0.13mmol/L respectively. No significant difference was found in serum chloride and phosphate levels (p>0.05). Conclusion: Sodium polystyrene sulphonate found to be effective in treating hyperkalemia and considerable changes in serum sodium level have been observed with minimal changes in serum magnesium and calcium levels.
format	article
author	Azfar Athar Ishaqui Masood Ahmed Khan Adnan Iqbal Syed Hameez Jawed Farah Khalid Mir Muhammad Uzairullah Muhammad Talha Usman Ashfaq Najam Zehra
author_facet	Azfar Athar Ishaqui Masood Ahmed Khan Adnan Iqbal Syed Hameez Jawed Farah Khalid Mir Muhammad Uzairullah Muhammad Talha Usman Ashfaq Najam Zehra
author_sort	Azfar Athar Ishaqui
title	EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
title_short	EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
title_full	EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
title_fullStr	EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
title_full_unstemmed	EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES
title_sort	evaluation of single dose sodium polystyrene sulfonate for management of hyperkalemia and its effect on other serum electrolytes
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/b9b082a6532f4c3cb2090f365eebc367
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EVALUATION OF SINGLE DOSE SODIUM POLYSTYRENE SULFONATE FOR MANAGEMENT OF HYPERKALEMIA AND ITS EFFECT ON OTHER SERUM ELECTROLYTES

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