Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure

Heart failure (HF), the leading cause of death among men and women world-wide, causes great health and economic burdens. HF can be triggered by many factors, such as coronary artery disease, heart attack, cardiomyopathy, hypertension, obesity, etc., all of which have close relations with calcium sig...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tianhao Yu, Danhua Huang, Haokun Wu, Haibin Chen, Sen Chen, Qingbin Cui
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	heart failure calcium overload ROS flavones treatment Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/b9b1b2d423a0402c854c8caea2181927
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b9b1b2d423a0402c854c8caea2181927
record_format	dspace
spelling	oai:doaj.org-article:b9b1b2d423a0402c854c8caea21819272021-11-09T06:50:01ZNavigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure1663-981210.3389/fphar.2021.718496https://doaj.org/article/b9b1b2d423a0402c854c8caea21819272021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.718496/fullhttps://doaj.org/toc/1663-9812Heart failure (HF), the leading cause of death among men and women world-wide, causes great health and economic burdens. HF can be triggered by many factors, such as coronary artery disease, heart attack, cardiomyopathy, hypertension, obesity, etc., all of which have close relations with calcium signal and the level of reactive oxygen species (ROS). Calcium is an essential second messenger in signaling pathways, playing a pivotal role in regulating the life and death of cardiomyocytes via the calcium-apoptosis link mediated by the cellular level of calcium. Meanwhile, calcium can also control the rate of energy production in mitochondria that are the major resources of ROS whose overproduction can lead to cell death. More importantly, there are bidirectional interactions between calcium and ROS, and such interactions may have therapeutic implications in treating HF through finely tuning the balance between these two by certain drugs. Many naturally derived products, e.g., flavones and isoflavones, have been shown to possess activities in regulating calcium and ROS simultaneously, thereby leading to a balanced microenvironment in heart tissues to exert therapeutic efficacies in HF. In this mini review, we aimed to provide an updated knowledge of the interplay between calcium and ROS in the development of HF. In addition, we summarized the recent studies (in vitro, in vivo and in clinical trials) using natural isolated flavones and isoflavones in treating HF. Critical challenges are also discussed. The information collected may help to evoke multidisciplinary efforts in developing novel agents for the potential prevention and treatment of HF.Tianhao YuDanhua HuangHaokun WuHaibin ChenSen ChenQingbin CuiFrontiers Media S.A.articleheart failurecalcium overloadROSflavonestreatmentTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heart failure calcium overload ROS flavones treatment Therapeutics. Pharmacology RM1-950
spellingShingle	heart failure calcium overload ROS flavones treatment Therapeutics. Pharmacology RM1-950 Tianhao Yu Danhua Huang Haokun Wu Haibin Chen Sen Chen Qingbin Cui Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
description	Heart failure (HF), the leading cause of death among men and women world-wide, causes great health and economic burdens. HF can be triggered by many factors, such as coronary artery disease, heart attack, cardiomyopathy, hypertension, obesity, etc., all of which have close relations with calcium signal and the level of reactive oxygen species (ROS). Calcium is an essential second messenger in signaling pathways, playing a pivotal role in regulating the life and death of cardiomyocytes via the calcium-apoptosis link mediated by the cellular level of calcium. Meanwhile, calcium can also control the rate of energy production in mitochondria that are the major resources of ROS whose overproduction can lead to cell death. More importantly, there are bidirectional interactions between calcium and ROS, and such interactions may have therapeutic implications in treating HF through finely tuning the balance between these two by certain drugs. Many naturally derived products, e.g., flavones and isoflavones, have been shown to possess activities in regulating calcium and ROS simultaneously, thereby leading to a balanced microenvironment in heart tissues to exert therapeutic efficacies in HF. In this mini review, we aimed to provide an updated knowledge of the interplay between calcium and ROS in the development of HF. In addition, we summarized the recent studies (in vitro, in vivo and in clinical trials) using natural isolated flavones and isoflavones in treating HF. Critical challenges are also discussed. The information collected may help to evoke multidisciplinary efforts in developing novel agents for the potential prevention and treatment of HF.
format	article
author	Tianhao Yu Danhua Huang Haokun Wu Haibin Chen Sen Chen Qingbin Cui
author_facet	Tianhao Yu Danhua Huang Haokun Wu Haibin Chen Sen Chen Qingbin Cui
author_sort	Tianhao Yu
title	Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
title_short	Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
title_full	Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
title_fullStr	Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
title_full_unstemmed	Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure
title_sort	navigating calcium and reactive oxygen species by natural flavones for the treatment of heart failure
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b9b1b2d423a0402c854c8caea2181927
work_keys_str_mv	AT tianhaoyu navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure AT danhuahuang navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure AT haokunwu navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure AT haibinchen navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure AT senchen navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure AT qingbincui navigatingcalciumandreactiveoxygenspeciesbynaturalflavonesforthetreatmentofheartfailure
_version_	1718441239212195840

Navigating Calcium and Reactive Oxygen Species by Natural Flavones for the Treatment of Heart Failure

Ejemplares similares