POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA

The aim of present work was to evaluate the effect of mesenchymal stromal cells (MSCs) from lymphoma patients on the in vitro and in vivo homeostatic proliferation of lymphocytes. Our data have demonstratedfor the first time, that MSCs from lymphoma patient are able to enhance the in vitro prolifera...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	E. V. Batorov, E. Ya. Shevela, M. A. Tikhonova, N. V. Pronkina, D. S. Batorova, I. V. Kryuchkova, T. I. Pospelova, A. A. Ostanin, E. R. Chernykh
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	mesenchymal stromal cells il-2 il-7 t-lymphocytes proliferation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b9b300ea5f4749a9a21a537a1d2b246e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b9b300ea5f4749a9a21a537a1d2b246e
record_format	dspace
spelling	oai:doaj.org-article:b9b300ea5f4749a9a21a537a1d2b246e2021-11-18T08:03:43ZPOSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA1563-06252313-741X10.15789/1563-0625-2014-2-139-148https://doaj.org/article/b9b300ea5f4749a9a21a537a1d2b246e2014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/679https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe aim of present work was to evaluate the effect of mesenchymal stromal cells (MSCs) from lymphoma patients on the in vitro and in vivo homeostatic proliferation of lymphocytes. Our data have demonstratedfor the first time, that MSCs from lymphoma patient are able to enhance the in vitro proliferation of donor and patient mononuclear cells (MNCs) in response to IL-2 or IL-7. This effect was observed within a wide rangeof MSC-to-MNC ratios (1:50-1:2). Lymphocyte reactivity to IL-2 or IL-7 was found to be an important factor determining the stimulatory effect of MSCs. Ex vivo studies in the patients undergoing autologous hematopoietic stem cell transplantation (AHSCT) have shown that the patients co-transplanted with MSCs exhibited higher proportions of proliferating CD8+T cells (especially, memory cells) at the day of engraftment, than before AHSCT, as compared to the patients subjected to standard AHSCT protocols. Moreover, there was no an increase in apoptosis of naive CD4+T cells that was typical for standard AHSCT. These data indicate that the stimulatory effect of MSCs upon T lymphocyte proliferation following chemotherapy-induced lymphopeniaconcerns, mainly, the memory CD8+T cell population, whereas more efficient recovery of naive CD4+T cells is due to anti-apoptotic effects of MSCs.E. V. BatorovE. Ya. ShevelaM. A. TikhonovaN. V. PronkinaD. S. BatorovaI. V. KryuchkovaT. I. PospelovaA. A. OstaninE. R. ChernykhSPb RAACIarticlemesenchymal stromal cellsil-2il-7t-lymphocytesproliferationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 2, Pp 139-148 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	mesenchymal stromal cells il-2 il-7 t-lymphocytes proliferation Immunologic diseases. Allergy RC581-607
spellingShingle	mesenchymal stromal cells il-2 il-7 t-lymphocytes proliferation Immunologic diseases. Allergy RC581-607 E. V. Batorov E. Ya. Shevela M. A. Tikhonova N. V. Pronkina D. S. Batorova I. V. Kryuchkova T. I. Pospelova A. A. Ostanin E. R. Chernykh POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
description	The aim of present work was to evaluate the effect of mesenchymal stromal cells (MSCs) from lymphoma patients on the in vitro and in vivo homeostatic proliferation of lymphocytes. Our data have demonstratedfor the first time, that MSCs from lymphoma patient are able to enhance the in vitro proliferation of donor and patient mononuclear cells (MNCs) in response to IL-2 or IL-7. This effect was observed within a wide rangeof MSC-to-MNC ratios (1:50-1:2). Lymphocyte reactivity to IL-2 or IL-7 was found to be an important factor determining the stimulatory effect of MSCs. Ex vivo studies in the patients undergoing autologous hematopoietic stem cell transplantation (AHSCT) have shown that the patients co-transplanted with MSCs exhibited higher proportions of proliferating CD8+T cells (especially, memory cells) at the day of engraftment, than before AHSCT, as compared to the patients subjected to standard AHSCT protocols. Moreover, there was no an increase in apoptosis of naive CD4+T cells that was typical for standard AHSCT. These data indicate that the stimulatory effect of MSCs upon T lymphocyte proliferation following chemotherapy-induced lymphopeniaconcerns, mainly, the memory CD8+T cell population, whereas more efficient recovery of naive CD4+T cells is due to anti-apoptotic effects of MSCs.
format	article
author	E. V. Batorov E. Ya. Shevela M. A. Tikhonova N. V. Pronkina D. S. Batorova I. V. Kryuchkova T. I. Pospelova A. A. Ostanin E. R. Chernykh
author_facet	E. V. Batorov E. Ya. Shevela M. A. Tikhonova N. V. Pronkina D. S. Batorova I. V. Kryuchkova T. I. Pospelova A. A. Ostanin E. R. Chernykh
author_sort	E. V. Batorov
title	POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
title_short	POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
title_full	POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
title_fullStr	POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
title_full_unstemmed	POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA
title_sort	possible mechanisms of stimulatory effects of mesenchymal stromal cells upon t cell recovery during chemotherapy-induced lymphopenia
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b9b300ea5f4749a9a21a537a1d2b246e
work_keys_str_mv	AT evbatorov possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT eyashevela possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT matikhonova possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT nvpronkina possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT dsbatorova possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT ivkryuchkova possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT tipospelova possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT aaostanin possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia AT erchernykh possiblemechanismsofstimulatoryeffectsofmesenchymalstromalcellsupontcellrecoveryduringchemotherapyinducedlymphopenia
_version_	1718422443803017216

POSSIBLE MECHANISMS OF STIMULATORY EFFECTS OF MESENCHYMAL STROMAL CELLS UPON T CELL RECOVERY DURING CHEMOTHERAPY-INDUCED LYMPHOPENIA

Ejemplares similares