Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cel...

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Autores principales:	Shimpei I. Kubota, Kei Takahashi, Tomoyuki Mano, Katsuhiko Matsumoto, Takahiro Katsumata, Shoi Shi, Kazuki Tainaka, Hiroki R. Ueda, Shogo Ehata, Kohei Miyazono
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11
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spelling	oai:doaj.org-article:b9b43d1be89a48cd9299b239e2a3ca112021-12-02T15:52:46ZWhole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing10.1038/s42003-021-01786-y2399-3642https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca112021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01786-yhttps://doaj.org/toc/2399-3642Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cellular microenvironment favouring metastatic invasion.Shimpei I. KubotaKei TakahashiTomoyuki ManoKatsuhiko MatsumotoTakahiro KatsumataShoi ShiKazuki TainakaHiroki R. UedaShogo EhataKohei MiyazonoNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Shimpei I. Kubota Kei Takahashi Tomoyuki Mano Katsuhiko Matsumoto Takahiro Katsumata Shoi Shi Kazuki Tainaka Hiroki R. Ueda Shogo Ehata Kohei Miyazono Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
description	Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cellular microenvironment favouring metastatic invasion.
format	article
author	Shimpei I. Kubota Kei Takahashi Tomoyuki Mano Katsuhiko Matsumoto Takahiro Katsumata Shoi Shi Kazuki Tainaka Hiroki R. Ueda Shogo Ehata Kohei Miyazono
author_facet	Shimpei I. Kubota Kei Takahashi Tomoyuki Mano Katsuhiko Matsumoto Takahiro Katsumata Shoi Shi Kazuki Tainaka Hiroki R. Ueda Shogo Ehata Kohei Miyazono
author_sort	Shimpei I. Kubota
title	Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
title_short	Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
title_full	Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
title_fullStr	Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
title_full_unstemmed	Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
title_sort	whole-organ analysis of tgf-β-mediated remodelling of the tumour microenvironment by tissue clearing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11
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Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing

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