Whole-organ analysis of TGF-β-mediated remodelling of the tumour microenvironment by tissue clearing
Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cel...
Enregistré dans:
Auteurs principaux: | Shimpei I. Kubota, Kei Takahashi, Tomoyuki Mano, Katsuhiko Matsumoto, Takahiro Katsumata, Shoi Shi, Kazuki Tainaka, Hiroki R. Ueda, Shogo Ehata, Kohei Miyazono |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/b9b43d1be89a48cd9299b239e2a3ca11 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis
par: Raymond K. H. Yip, et autres
Publié: (2021) -
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry
par: Febe van Maldegem, et autres
Publié: (2021) -
The temporal mutational and immune tumour microenvironment remodelling of HER2-negative primary breast cancers
par: Leticia De Mattos-Arruda, et autres
Publié: (2021) -
Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment
par: Min Zhang, et autres
Publié: (2021) -
Tumour Microenvironment Stress Promotes the Development of Drug Resistance
par: Nicole A. Seebacher, et autres
Publié: (2021)