Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the viral oncogene Tax.

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Autores principales:	Lamya Ben Ameur, Paul Marie, Morgan Thenoz, Guillaume Giraud, Emmanuel Combe, Jean-Baptiste Claude, Sebastien Lemaire, Nicolas Fontrodona, Hélène Polveche, Marine Bastien, Antoine Gessain, Eric Wattel, Cyril F. Bourgeois, Didier Auboeuf, Franck Mortreux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9b58d9a3e674e579917447295972cb5
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spelling	oai:doaj.org-article:b9b58d9a3e674e579917447295972cb52021-12-02T17:40:27ZIntragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-110.1038/s41467-020-16853-x2041-1723https://doaj.org/article/b9b58d9a3e674e579917447295972cb52020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16853-xhttps://doaj.org/toc/2041-1723The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the viral oncogene Tax.Lamya Ben AmeurPaul MarieMorgan ThenozGuillaume GiraudEmmanuel CombeJean-Baptiste ClaudeSebastien LemaireNicolas FontrodonaHélène PolvecheMarine BastienAntoine GessainEric WattelCyril F. BourgeoisDidier AuboeufFranck MortreuxNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lamya Ben Ameur Paul Marie Morgan Thenoz Guillaume Giraud Emmanuel Combe Jean-Baptiste Claude Sebastien Lemaire Nicolas Fontrodona Hélène Polveche Marine Bastien Antoine Gessain Eric Wattel Cyril F. Bourgeois Didier Auboeuf Franck Mortreux Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
description	The nuclear factors κB (NF-κB) is a transcription factor involved in immune functions, inflammation, and cancer. Here, the authors show that the NF-κB factor RELA regulates splicing of target genes by recruiting DDX17 on chromatin upon expression of the viral oncogene Tax.
format	article
author	Lamya Ben Ameur Paul Marie Morgan Thenoz Guillaume Giraud Emmanuel Combe Jean-Baptiste Claude Sebastien Lemaire Nicolas Fontrodona Hélène Polveche Marine Bastien Antoine Gessain Eric Wattel Cyril F. Bourgeois Didier Auboeuf Franck Mortreux
author_facet	Lamya Ben Ameur Paul Marie Morgan Thenoz Guillaume Giraud Emmanuel Combe Jean-Baptiste Claude Sebastien Lemaire Nicolas Fontrodona Hélène Polveche Marine Bastien Antoine Gessain Eric Wattel Cyril F. Bourgeois Didier Auboeuf Franck Mortreux
author_sort	Lamya Ben Ameur
title	Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
title_short	Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
title_full	Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
title_fullStr	Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
title_full_unstemmed	Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1
title_sort	intragenic recruitment of nf-κb drives splicing modifications upon activation by the oncogene tax of htlv-1
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b9b58d9a3e674e579917447295972cb5
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Intragenic recruitment of NF-κB drives splicing modifications upon activation by the oncogene Tax of HTLV-1

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