Metagenomic analysis of the ferret fecal viral flora.

Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics approach. Novel viruses from the families Picorna-, P...

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Autores principales:	Saskia L Smits, V Stalin Raj, Minoushka D Oduber, Claudia M E Schapendonk, Rogier Bodewes, Lisette Provacia, Koert J Stittelaar, Albert D M E Osterhaus, Bart L Haagmans
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9ba5f9df5674c99852e4e3c10c50ac0
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spelling	oai:doaj.org-article:b9ba5f9df5674c99852e4e3c10c50ac02021-11-18T08:58:50ZMetagenomic analysis of the ferret fecal viral flora.1932-620310.1371/journal.pone.0071595https://doaj.org/article/b9ba5f9df5674c99852e4e3c10c50ac02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977082/?tool=EBIhttps://doaj.org/toc/1932-6203Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics approach. Novel viruses from the families Picorna-, Papilloma-, and Anelloviridae as well as known viruses from the families Astro-, Corona-, Parvo-, and Hepeviridae were identified in different ferret cohorts. Ferret kobu- and hepatitis E virus were mainly present in human household ferrets, whereas coronaviruses were found both in household as well as farm ferrets. Our studies illuminate the viral diversity found in ferrets and provide tools to prescreen for newly identified viruses that potentially could influence disease outcome of experimental virus infections in ferrets.Saskia L SmitsV Stalin RajMinoushka D OduberClaudia M E SchapendonkRogier BodewesLisette ProvaciaKoert J StittelaarAlbert D M E OsterhausBart L HaagmansPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71595 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Saskia L Smits V Stalin Raj Minoushka D Oduber Claudia M E Schapendonk Rogier Bodewes Lisette Provacia Koert J Stittelaar Albert D M E Osterhaus Bart L Haagmans Metagenomic analysis of the ferret fecal viral flora.
description	Ferrets are widely used as a small animal model for a number of viral infections, including influenza A virus and SARS coronavirus. To further analyze the microbiological status of ferrets, their fecal viral flora was studied using a metagenomics approach. Novel viruses from the families Picorna-, Papilloma-, and Anelloviridae as well as known viruses from the families Astro-, Corona-, Parvo-, and Hepeviridae were identified in different ferret cohorts. Ferret kobu- and hepatitis E virus were mainly present in human household ferrets, whereas coronaviruses were found both in household as well as farm ferrets. Our studies illuminate the viral diversity found in ferrets and provide tools to prescreen for newly identified viruses that potentially could influence disease outcome of experimental virus infections in ferrets.
format	article
author	Saskia L Smits V Stalin Raj Minoushka D Oduber Claudia M E Schapendonk Rogier Bodewes Lisette Provacia Koert J Stittelaar Albert D M E Osterhaus Bart L Haagmans
author_facet	Saskia L Smits V Stalin Raj Minoushka D Oduber Claudia M E Schapendonk Rogier Bodewes Lisette Provacia Koert J Stittelaar Albert D M E Osterhaus Bart L Haagmans
author_sort	Saskia L Smits
title	Metagenomic analysis of the ferret fecal viral flora.
title_short	Metagenomic analysis of the ferret fecal viral flora.
title_full	Metagenomic analysis of the ferret fecal viral flora.
title_fullStr	Metagenomic analysis of the ferret fecal viral flora.
title_full_unstemmed	Metagenomic analysis of the ferret fecal viral flora.
title_sort	metagenomic analysis of the ferret fecal viral flora.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b9ba5f9df5674c99852e4e3c10c50ac0
work_keys_str_mv	AT saskialsmits metagenomicanalysisoftheferretfecalviralflora AT vstalinraj metagenomicanalysisoftheferretfecalviralflora AT minoushkadoduber metagenomicanalysisoftheferretfecalviralflora AT claudiameschapendonk metagenomicanalysisoftheferretfecalviralflora AT rogierbodewes metagenomicanalysisoftheferretfecalviralflora AT lisetteprovacia metagenomicanalysisoftheferretfecalviralflora AT koertjstittelaar metagenomicanalysisoftheferretfecalviralflora AT albertdmeosterhaus metagenomicanalysisoftheferretfecalviralflora AT bartlhaagmans metagenomicanalysisoftheferretfecalviralflora
_version_	1718421105981521920

Metagenomic analysis of the ferret fecal viral flora.

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