The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II

Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes w...

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Autores principales: Takeshi Nakatani, Kohei Tsujimoto, JeongHoon Park, Tatsunori Jo, Tetsuya Kimura, Yoshitomo Hayama, Hachiro Konaka, Takayoshi Morita, Yasuhiro Kato, Masayuki Nishide, Shyohei Koyama, Shigeyuki Nada, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/b9bae71b307d4e098ab61ae9cbe22e83
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spelling oai:doaj.org-article:b9bae71b307d4e098ab61ae9cbe22e832021-12-02T17:38:25ZThe lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II10.1038/s41467-021-23654-32041-1723https://doaj.org/article/b9bae71b307d4e098ab61ae9cbe22e832021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23654-3https://doaj.org/toc/2041-1723Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).Takeshi NakataniKohei TsujimotoJeongHoon ParkTatsunori JoTetsuya KimuraYoshitomo HayamaHachiro KonakaTakayoshi MoritaYasuhiro KatoMasayuki NishideShyohei KoyamaShigeyuki NadaMasato OkadaHyota TakamatsuAtsushi KumanogohNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Takeshi Nakatani
Kohei Tsujimoto
JeongHoon Park
Tatsunori Jo
Tetsuya Kimura
Yoshitomo Hayama
Hachiro Konaka
Takayoshi Morita
Yasuhiro Kato
Masayuki Nishide
Shyohei Koyama
Shigeyuki Nada
Masato Okada
Hyota Takamatsu
Atsushi Kumanogoh
The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
description Myosin II–mediated contractility is required for leukocyte migration. Here, authors show that lysosomes are involved in leukocyte migration by providing the platform where Ragulator complex interacts with the myosin phosphatase Rho-interacting protein (MPRIP) independently of mTORC1 and interferes with the interaction between MPRIP and a subunit of myosin light chain phosphatase (MLCP).
format article
author Takeshi Nakatani
Kohei Tsujimoto
JeongHoon Park
Tatsunori Jo
Tetsuya Kimura
Yoshitomo Hayama
Hachiro Konaka
Takayoshi Morita
Yasuhiro Kato
Masayuki Nishide
Shyohei Koyama
Shigeyuki Nada
Masato Okada
Hyota Takamatsu
Atsushi Kumanogoh
author_facet Takeshi Nakatani
Kohei Tsujimoto
JeongHoon Park
Tatsunori Jo
Tetsuya Kimura
Yoshitomo Hayama
Hachiro Konaka
Takayoshi Morita
Yasuhiro Kato
Masayuki Nishide
Shyohei Koyama
Shigeyuki Nada
Masato Okada
Hyota Takamatsu
Atsushi Kumanogoh
author_sort Takeshi Nakatani
title The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
title_short The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
title_full The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
title_fullStr The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
title_full_unstemmed The lysosomal Ragulator complex plays an essential role in leukocyte trafficking by activating myosin II
title_sort lysosomal ragulator complex plays an essential role in leukocyte trafficking by activating myosin ii
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/b9bae71b307d4e098ab61ae9cbe22e83
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