Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

Arunpandian Balaji, Saravana Kumar Jaganathan, Eko Supriyanto, Ida Idayu Muhamad, Ahmad Zahran Md Khudzari Institut Jantung Negara-Universiti Teknologi Malaysia, Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia...

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Autores principales:	Balaji A, Jaganathan SK, Supriyanto E, Muhamad II, Khudzari AZM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9bbcca4fc6e4d0c815e76f374d70c17
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spelling	oai:doaj.org-article:b9bbcca4fc6e4d0c815e76f374d70c172021-12-02T05:40:44ZMicrowave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications1178-2013https://doaj.org/article/b9bbcca4fc6e4d0c815e76f374d70c172015-09-01T00:00:00Zhttps://www.dovepress.com/microwave-assisted-fibrous-decoration-of-mpe-surface-utilizing-aloe-ve-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Arunpandian Balaji, Saravana Kumar Jaganathan, Eko Supriyanto, Ida Idayu Muhamad, Ahmad Zahran Md Khudzari Institut Jantung Negara-Universiti Teknologi Malaysia, Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia Abstract: Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants. Keywords: Metallocene polyethylene, fibrous coating, physicochemical properties, blood compatibilityBalaji AJaganathan SKSupriyanto EMuhamad IIKhudzari AZMDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 5909-5923 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Balaji A Jaganathan SK Supriyanto E Muhamad II Khudzari AZM Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
description	Arunpandian Balaji, Saravana Kumar Jaganathan, Eko Supriyanto, Ida Idayu Muhamad, Ahmad Zahran Md Khudzari Institut Jantung Negara-Universiti Teknologi Malaysia, Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Johor Bahru, Malaysia Abstract: Developing multifaceted, biocompatible, artificial implants for tissue engineering is a growing field of research. In recent times, several works have been reported about the utilization of biomolecules in combination with synthetic materials to achieve this process. Accordingly, in this study, the ability of an extract obtained from Aloe vera, a commonly used medicinal plant in influencing the biocompatibility of artificial material, is scrutinized using metallocene polyethylene (mPE). The process of coating dense fibrous Aloe vera extract on the surface of mPE was carried out using microwaves. Then, several physicochemical and blood compatibility characterization experiments were performed to disclose the effects of corresponding surface modification. The Fourier transform infrared spectrum showed characteristic vibrations of several active constituents available in Aloe vera and exhibited peak shifts at far infrared regions due to aloe-based mineral deposition. Meanwhile, the contact angle analysis demonstrated a drastic increase in wettability of coated samples, which confirmed the presence of active components on glazed mPE surface. Moreover, the bio-mimic structure of Aloe vera fibers and the influence of microwaves in enhancing the coating characteristics were also meticulously displayed through scanning electron microscopy micrographs and Hirox 3D images. The existence of nanoscale roughness was interpreted through high-resolution profiles obtained from atomic force microscopy. And the extent of variations in irregularities was delineated by measuring average roughness. Aloe vera-induced enrichment in the hemocompatible properties of mPE was established by carrying out in vitro tests such as activated partial thromboplastin time, prothrombin time, platelet adhesion, and hemolysis assay. In conclusion, the Aloe vera-glazed mPE substrate was inferred to attain desirable properties required for multifaceted biomedical implants. Keywords: Metallocene polyethylene, fibrous coating, physicochemical properties, blood compatibility
format	article
author	Balaji A Jaganathan SK Supriyanto E Muhamad II Khudzari AZM
author_facet	Balaji A Jaganathan SK Supriyanto E Muhamad II Khudzari AZM
author_sort	Balaji A
title	Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
title_short	Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
title_full	Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
title_fullStr	Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
title_full_unstemmed	Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications
title_sort	microwave-assisted fibrous decoration of mpe surface utilizing aloe vera extract for tissue engineering applications
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/b9bbcca4fc6e4d0c815e76f374d70c17
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Microwave-assisted fibrous decoration of mPE surface utilizing Aloe vera extract for tissue engineering applications

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