The risk of pancreatic adenocarcinoma following SARS-CoV family infection

Abstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complicati...

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Autores principales:	Amin Ebrahimi Sadrabadi, Ahmad Bereimipour, Arsalan Jalili, Mazaher Gholipurmalekabadi, Behrouz Farhadihosseinabadi, Alexander M. Seifalian
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9bc72f639824761b1d31205d295689d
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spelling	oai:doaj.org-article:b9bc72f639824761b1d31205d295689d2021-12-02T17:14:24ZThe risk of pancreatic adenocarcinoma following SARS-CoV family infection10.1038/s41598-021-92068-42045-2322https://doaj.org/article/b9bc72f639824761b1d31205d295689d2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92068-4https://doaj.org/toc/2045-2322Abstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aimed to evaluate the possible correlation between infection with SARS-CoV viruses and cancer in an in-silico study model. To do this, the relevent dataset was selected from GEO database. Identification of differentially expressed genes among defined groups including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1 were screened where the \|Log FC\| ≥ 1and p < 0.05 were considered statistically significant. Later, the pathway enrichment analysis and gene ontology (GO) were used by Enrichr and Shiny GO databases. Evaluation with STRING online was applied to predict the functional interactions of proteins, followed by Cytoscape analysis to identify the master genes. Finally, analysis with GEPIA2 server was carried out to reveal the possible correlation between candidate genes and cancer development. The results showed that the main molecular function of up- and down-regulated genes was “double-stranded RNA binding” and actin-binding, respectively. STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. According to TCGA database results, these four genes were up-regulated notably in pancreatic adenocarcinoma. Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family.Amin Ebrahimi SadrabadiAhmad BereimipourArsalan JaliliMazaher GholipurmalekabadiBehrouz FarhadihosseinabadiAlexander M. SeifalianNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian The risk of pancreatic adenocarcinoma following SARS-CoV family infection
description	Abstract COVID 19 disease has become a global catastrophe over the past year that has claimed the lives of over two million people around the world. Despite the introduction of vaccines against the disease, there is still a long way to completely eradicate it. There are concerns about the complications following infection with SARS-CoV-2. This research aimed to evaluate the possible correlation between infection with SARS-CoV viruses and cancer in an in-silico study model. To do this, the relevent dataset was selected from GEO database. Identification of differentially expressed genes among defined groups including SARS-CoV, SARS-dORF6, SARS-BatSRBD, and H1N1 were screened where the \|Log FC\| ≥ 1and p < 0.05 were considered statistically significant. Later, the pathway enrichment analysis and gene ontology (GO) were used by Enrichr and Shiny GO databases. Evaluation with STRING online was applied to predict the functional interactions of proteins, followed by Cytoscape analysis to identify the master genes. Finally, analysis with GEPIA2 server was carried out to reveal the possible correlation between candidate genes and cancer development. The results showed that the main molecular function of up- and down-regulated genes was “double-stranded RNA binding” and actin-binding, respectively. STRING and Cytoscape analysis presented four genes, PTEN, CREB1, CASP3, and SMAD3 as the key genes involved in cancer development. According to TCGA database results, these four genes were up-regulated notably in pancreatic adenocarcinoma. Our findings suggest that pancreatic adenocarcinoma is the most probably malignancy happening after infection with SARS-CoV family.
format	article
author	Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian
author_facet	Amin Ebrahimi Sadrabadi Ahmad Bereimipour Arsalan Jalili Mazaher Gholipurmalekabadi Behrouz Farhadihosseinabadi Alexander M. Seifalian
author_sort	Amin Ebrahimi Sadrabadi
title	The risk of pancreatic adenocarcinoma following SARS-CoV family infection
title_short	The risk of pancreatic adenocarcinoma following SARS-CoV family infection
title_full	The risk of pancreatic adenocarcinoma following SARS-CoV family infection
title_fullStr	The risk of pancreatic adenocarcinoma following SARS-CoV family infection
title_full_unstemmed	The risk of pancreatic adenocarcinoma following SARS-CoV family infection
title_sort	risk of pancreatic adenocarcinoma following sars-cov family infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9bc72f639824761b1d31205d295689d
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The risk of pancreatic adenocarcinoma following SARS-CoV family infection

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