High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity

Abstract Nonalcoholic steatohepatitis (NASH) and glucose intolerance are associated with an increased risk of mortality in patients with severe obesity; however, whether histological findings of the liver are related to glucose intolerance in these patients remain unknown. Sixty-nine consecutive pat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Keisuke Kakisaka, Akira Sasaki, Akira Umemura, Haruka Nikai, Yuji Suzuki, Masao Nishiya, Tamotsu Sugai, Hiroyuki Nitta, Yasuhiro Takikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b9c242705e4545579867dbfd543e0da1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b9c242705e4545579867dbfd543e0da1
record_format	dspace
spelling	oai:doaj.org-article:b9c242705e4545579867dbfd543e0da12021-12-02T18:47:10ZHigh frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity10.1038/s41598-021-94937-42045-2322https://doaj.org/article/b9c242705e4545579867dbfd543e0da12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94937-4https://doaj.org/toc/2045-2322Abstract Nonalcoholic steatohepatitis (NASH) and glucose intolerance are associated with an increased risk of mortality in patients with severe obesity; however, whether histological findings of the liver are related to glucose intolerance in these patients remain unknown. Sixty-nine consecutive patients who underwent metabolic surgery between June 2008 and February 2020 were included; histological findings of the liver and laboratory data were analyzed. Twenty patients with biopsy-proven NASH were chronologically evaluated using sequential biopsies; data before metabolic surgery was considered as the baseline. Glucose intolerance—demonstrated by an increased area under the curve (AUC) for blood sugar (BS) during the 75-g oral glucose tolerance test—and increased homeostatic model assessment for insulin resistance (HOMA-IR) correlated with the grade of hepatocyte ballooning in patients. Patients with persistent ballooning at the follow-up biopsy had a higher HOMA-IR, high AUC for BS, and lower adiponectin level than those in patients in whom ballooning was eliminated, while there was no significant difference in body weight. We concluded that glucose intolerance was associated with the grade of hepatocyte ballooning; additionally, persistent hepatocyte ballooning sustained glucose intolerance, while elimination of hepatocyte ballooning improved the condition. Glucose intolerance may, thus, mediate balloon formation of the hepatocyte.Keisuke KakisakaAkira SasakiAkira UmemuraHaruka NikaiYuji SuzukiMasao NishiyaTamotsu SugaiHiroyuki NittaYasuhiro TakikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keisuke Kakisaka Akira Sasaki Akira Umemura Haruka Nikai Yuji Suzuki Masao Nishiya Tamotsu Sugai Hiroyuki Nitta Yasuhiro Takikawa High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
description	Abstract Nonalcoholic steatohepatitis (NASH) and glucose intolerance are associated with an increased risk of mortality in patients with severe obesity; however, whether histological findings of the liver are related to glucose intolerance in these patients remain unknown. Sixty-nine consecutive patients who underwent metabolic surgery between June 2008 and February 2020 were included; histological findings of the liver and laboratory data were analyzed. Twenty patients with biopsy-proven NASH were chronologically evaluated using sequential biopsies; data before metabolic surgery was considered as the baseline. Glucose intolerance—demonstrated by an increased area under the curve (AUC) for blood sugar (BS) during the 75-g oral glucose tolerance test—and increased homeostatic model assessment for insulin resistance (HOMA-IR) correlated with the grade of hepatocyte ballooning in patients. Patients with persistent ballooning at the follow-up biopsy had a higher HOMA-IR, high AUC for BS, and lower adiponectin level than those in patients in whom ballooning was eliminated, while there was no significant difference in body weight. We concluded that glucose intolerance was associated with the grade of hepatocyte ballooning; additionally, persistent hepatocyte ballooning sustained glucose intolerance, while elimination of hepatocyte ballooning improved the condition. Glucose intolerance may, thus, mediate balloon formation of the hepatocyte.
format	article
author	Keisuke Kakisaka Akira Sasaki Akira Umemura Haruka Nikai Yuji Suzuki Masao Nishiya Tamotsu Sugai Hiroyuki Nitta Yasuhiro Takikawa
author_facet	Keisuke Kakisaka Akira Sasaki Akira Umemura Haruka Nikai Yuji Suzuki Masao Nishiya Tamotsu Sugai Hiroyuki Nitta Yasuhiro Takikawa
author_sort	Keisuke Kakisaka
title	High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
title_short	High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
title_full	High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
title_fullStr	High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
title_full_unstemmed	High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
title_sort	high frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b9c242705e4545579867dbfd543e0da1
work_keys_str_mv	AT keisukekakisaka highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT akirasasaki highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT akiraumemura highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT harukanikai highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT yujisuzuki highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT masaonishiya highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT tamotsusugai highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT hiroyukinitta highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity AT yasuhirotakikawa highfrequencyandlongpersistencyofballooninghepatocytewereassociatedwithglucoseintoleranceinpatientswithsevereobesity
_version_	1718377645616398336

High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity

Ejemplares similares