Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making

Ikenna I Nnabugwu,1,2 Fred O Ugwumba,1 Oghenekaro A Enivwenae,2 Emeka I Udeh,1 Chris O Otene,2 Chinwe A Nnabugwu3 1Urology Unit, Department of Surgery, College of Medicine, University of Nigeria, Nsukka, 2Urology Unit, Department of Surgery, 3Department of Medical Laboratory Services, Federal Medica...

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Autores principales:	Nnabugwu II, Ugwumba FO, Enivwenae OA, Udeh EI, Otene CO, Nnabugwu CA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	tPSA symptomatic prostate enlargement prostate histology. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/b9c334cd5b9847acbb8037a7d2b74d44
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spelling	oai:doaj.org-article:b9c334cd5b9847acbb8037a7d2b74d442021-12-02T04:07:44ZSerum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making1178-1998https://doaj.org/article/b9c334cd5b9847acbb8037a7d2b74d442014-12-01T00:00:00Zhttps://www.dovepress.com/serum-total-prostate-specific-antigen-values-in-men-with-symptomatic-p-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Ikenna I Nnabugwu,1,2 Fred O Ugwumba,1 Oghenekaro A Enivwenae,2 Emeka I Udeh,1 Chris O Otene,2 Chinwe A Nnabugwu3 1Urology Unit, Department of Surgery, College of Medicine, University of Nigeria, Nsukka, 2Urology Unit, Department of Surgery, 3Department of Medical Laboratory Services, Federal Medical Centre, Asaba, Nigeria Background: Prostatic enlargement is a common cause of bladder outlet obstruction in men in Nigeria. Malignant enlargements must be differentiated from benign enlargements for adequate treatment of each patient. High serum total prostate-specific antigen (tPSA) levels suggest malignancy, but some of the biopsies done due to a serum tPSA value >4 ng/mL would be negative for malignancy because of the low specificity of tPSA for prostate cancer. This study aims to compare the histologic findings of all prostate specimens obtained from core needle biopsy, open simple prostatectomy, and transurethral resection of the prostate with the respective serum tPSA values in an attempt to decipher the role of serum tPSA in the management of these patients.Methods: The case notes of patients attended to from April 2009 to March 2012 were analyzed. Essentially, the age of the patient, findings on digital rectal examination, abdominopelvic ultrasonography report on the prostate, serum tPSA, and histology reports from biopsy or prostatectomy specimens as indicated were extracted for analysis.Results: The relationship between age, findings on digital rectal examination, serum tPSA, abdominopelvic ultrasonography report, and histology are compared. A statistically significant relationship existed between a malignant histology and age 65 years and older, suspicious findings on digital rectal examination, suspicious ultrasonography findings, and serum tPSA >10 ng/mL, but not tPSA >4 ng/mL.Conclusion: In Nigerian patients with symptomatic prostate enlargement, serum tPSA should be seen as a continuum with increasing risk of prostate malignancy. Keywords: serum total prostate-specific antigen, symptomatic prostate enlargement, prostate histologyNnabugwu IIUgwumba FOEnivwenae OAUdeh EIOtene CONnabugwu CADove Medical PressarticletPSAsymptomatic prostate enlargementprostate histology.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 10, Pp 89-93 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	tPSA symptomatic prostate enlargement prostate histology. Geriatrics RC952-954.6
spellingShingle	tPSA symptomatic prostate enlargement prostate histology. Geriatrics RC952-954.6 Nnabugwu II Ugwumba FO Enivwenae OA Udeh EI Otene CO Nnabugwu CA Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
description	Ikenna I Nnabugwu,1,2 Fred O Ugwumba,1 Oghenekaro A Enivwenae,2 Emeka I Udeh,1 Chris O Otene,2 Chinwe A Nnabugwu3 1Urology Unit, Department of Surgery, College of Medicine, University of Nigeria, Nsukka, 2Urology Unit, Department of Surgery, 3Department of Medical Laboratory Services, Federal Medical Centre, Asaba, Nigeria Background: Prostatic enlargement is a common cause of bladder outlet obstruction in men in Nigeria. Malignant enlargements must be differentiated from benign enlargements for adequate treatment of each patient. High serum total prostate-specific antigen (tPSA) levels suggest malignancy, but some of the biopsies done due to a serum tPSA value >4 ng/mL would be negative for malignancy because of the low specificity of tPSA for prostate cancer. This study aims to compare the histologic findings of all prostate specimens obtained from core needle biopsy, open simple prostatectomy, and transurethral resection of the prostate with the respective serum tPSA values in an attempt to decipher the role of serum tPSA in the management of these patients.Methods: The case notes of patients attended to from April 2009 to March 2012 were analyzed. Essentially, the age of the patient, findings on digital rectal examination, abdominopelvic ultrasonography report on the prostate, serum tPSA, and histology reports from biopsy or prostatectomy specimens as indicated were extracted for analysis.Results: The relationship between age, findings on digital rectal examination, serum tPSA, abdominopelvic ultrasonography report, and histology are compared. A statistically significant relationship existed between a malignant histology and age 65 years and older, suspicious findings on digital rectal examination, suspicious ultrasonography findings, and serum tPSA >10 ng/mL, but not tPSA >4 ng/mL.Conclusion: In Nigerian patients with symptomatic prostate enlargement, serum tPSA should be seen as a continuum with increasing risk of prostate malignancy. Keywords: serum total prostate-specific antigen, symptomatic prostate enlargement, prostate histology
format	article
author	Nnabugwu II Ugwumba FO Enivwenae OA Udeh EI Otene CO Nnabugwu CA
author_facet	Nnabugwu II Ugwumba FO Enivwenae OA Udeh EI Otene CO Nnabugwu CA
author_sort	Nnabugwu II
title	Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
title_short	Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
title_full	Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
title_fullStr	Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
title_full_unstemmed	Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making
title_sort	serum total prostate-specific antigen values in men with symptomatic prostate enlargement in nigeria: role in clinical decision-making
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/b9c334cd5b9847acbb8037a7d2b74d44
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Serum total prostate-specific antigen values in men with symptomatic prostate enlargement in Nigeria: role in clinical decision-making

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