SARS-CoV-2 involvement in central nervous system tissue damage

As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs...

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Autores principales:	Muhammad Ali Haidar, Zaynab Shakkour, Mohammad Amine Reslan, Nadine Al-Haj, Perla Chamoun, Karl Habashy, Hasan Kaafarani, Shima Shahjouei, Sarah H Farran, Abdullah Shaito, Esber S Saba, Bassam Badran, Mirna Sabra, Firas Kobeissy, Maya Bizri
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	autoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathy Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/b9c38d3b50f64de6ad023ecc3e419373
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spelling	oai:doaj.org-article:b9c38d3b50f64de6ad023ecc3e4193732021-11-19T12:16:44ZSARS-CoV-2 involvement in central nervous system tissue damage1673-537410.4103/1673-5374.327323https://doaj.org/article/b9c38d3b50f64de6ad023ecc3e4193732022-01-01T00:00:00Zhttp://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=6;spage=1228;epage=1239;aulast=Haidarhttps://doaj.org/toc/1673-5374As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.Muhammad Ali HaidarZaynab ShakkourMohammad Amine ReslanNadine Al-HajPerla ChamounKarl HabashyHasan KaafaraniShima ShahjoueiSarah H FarranAbdullah ShaitoEsber S SabaBassam BadranMirna SabraFiras KobeissyMaya BizriWolters Kluwer Medknow Publicationsarticleautoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathyNeurology. Diseases of the nervous systemRC346-429ENNeural Regeneration Research, Vol 17, Iss 6, Pp 1228-1239 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	autoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathy Neurology. Diseases of the nervous system RC346-429
spellingShingle	autoantibodies; cns infection; coagulopathy; covid-19; encephalitis; neuroinflammation; renin-angiotensin system; viral encephalopathy Neurology. Diseases of the nervous system RC346-429 Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah H Farran Abdullah Shaito Esber S Saba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri SARS-CoV-2 involvement in central nervous system tissue damage
description	As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.
format	article
author	Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah H Farran Abdullah Shaito Esber S Saba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri
author_facet	Muhammad Ali Haidar Zaynab Shakkour Mohammad Amine Reslan Nadine Al-Haj Perla Chamoun Karl Habashy Hasan Kaafarani Shima Shahjouei Sarah H Farran Abdullah Shaito Esber S Saba Bassam Badran Mirna Sabra Firas Kobeissy Maya Bizri
author_sort	Muhammad Ali Haidar
title	SARS-CoV-2 involvement in central nervous system tissue damage
title_short	SARS-CoV-2 involvement in central nervous system tissue damage
title_full	SARS-CoV-2 involvement in central nervous system tissue damage
title_fullStr	SARS-CoV-2 involvement in central nervous system tissue damage
title_full_unstemmed	SARS-CoV-2 involvement in central nervous system tissue damage
title_sort	sars-cov-2 involvement in central nervous system tissue damage
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/b9c38d3b50f64de6ad023ecc3e419373
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SARS-CoV-2 involvement in central nervous system tissue damage

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