Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria

Estrogen therapy is widely used as a supplementary treatment after hysteroscopy for female infertility patients owing to its protective function that improves endometrial regeneration and menstruation, inhibits recurrent adhesions, and improves subsequent conception rate. The endometrial protective...

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Autores principales:	Yingxin Zheng, Yuemeng Zhu, Ting Zhuge, Bin Li, Chao Gu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	metabolomics estrogen treatment hysteroscopy pentose phosphate pathway 6-aminonicotinamide Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/b9c6876589074ba0a35e5557b12cb184
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spelling	oai:doaj.org-article:b9c6876589074ba0a35e5557b12cb1842021-11-15T06:50:45ZMetabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria1664-239210.3389/fendo.2021.791174https://doaj.org/article/b9c6876589074ba0a35e5557b12cb1842021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.791174/fullhttps://doaj.org/toc/1664-2392Estrogen therapy is widely used as a supplementary treatment after hysteroscopy for female infertility patients owing to its protective function that improves endometrial regeneration and menstruation, inhibits recurrent adhesions, and improves subsequent conception rate. The endometrial protective function of such estrogen administration pre-surgery is still controversial. In the current study, 12 infertility patients were enrolled, who were treated with estrogen before hysteroscopy surgery. Using cutting-edge metabolomic analysis, we observed alterations in the pentose phosphate pathway (PPP) intermediates of the patient’s endometrial tissues. Furthermore, using Ishikawa endometrial cells, we validated our clinical discovery and identified estrogen–ESR–G6PD–PPP axial function, which promotes estrogen-induced cell proliferation.Yingxin ZhengYingxin ZhengYuemeng ZhuYuemeng ZhuTing ZhugeTing ZhugeBin LiBin LiChao GuChao GuFrontiers Media S.A.articlemetabolomicsestrogen treatmenthysteroscopypentose phosphate pathway6-aminonicotinamideDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics estrogen treatment hysteroscopy pentose phosphate pathway 6-aminonicotinamide Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	metabolomics estrogen treatment hysteroscopy pentose phosphate pathway 6-aminonicotinamide Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yingxin Zheng Yingxin Zheng Yuemeng Zhu Yuemeng Zhu Ting Zhuge Ting Zhuge Bin Li Bin Li Chao Gu Chao Gu Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
description	Estrogen therapy is widely used as a supplementary treatment after hysteroscopy for female infertility patients owing to its protective function that improves endometrial regeneration and menstruation, inhibits recurrent adhesions, and improves subsequent conception rate. The endometrial protective function of such estrogen administration pre-surgery is still controversial. In the current study, 12 infertility patients were enrolled, who were treated with estrogen before hysteroscopy surgery. Using cutting-edge metabolomic analysis, we observed alterations in the pentose phosphate pathway (PPP) intermediates of the patient’s endometrial tissues. Furthermore, using Ishikawa endometrial cells, we validated our clinical discovery and identified estrogen–ESR–G6PD–PPP axial function, which promotes estrogen-induced cell proliferation.
format	article
author	Yingxin Zheng Yingxin Zheng Yuemeng Zhu Yuemeng Zhu Ting Zhuge Ting Zhuge Bin Li Bin Li Chao Gu Chao Gu
author_facet	Yingxin Zheng Yingxin Zheng Yuemeng Zhu Yuemeng Zhu Ting Zhuge Ting Zhuge Bin Li Bin Li Chao Gu Chao Gu
author_sort	Yingxin Zheng
title	Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
title_short	Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
title_full	Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
title_fullStr	Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
title_full_unstemmed	Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria
title_sort	metabolomics analysis discovers estrogen altering cell proliferation via the pentose phosphate pathway in infertility patient endometria
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b9c6876589074ba0a35e5557b12cb184
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Metabolomics Analysis Discovers Estrogen Altering Cell Proliferation via the Pentose Phosphate Pathway in Infertility Patient Endometria

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