Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen

How pathogens maintain phenotypic robustness during infection is poorly understood. Here the authors couple the virulence regulatory network (VRN) of the pathogen R. solanacearum to a model of its metabolic network, and find that the VRN activates functionally redundant primary metabolism genes to p...

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Autores principales:	Rémi Peyraud, Ludovic Cottret, Lucas Marmiesse, Stéphane Genin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9c74857e4914428bf5c350db3854c46
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spelling	oai:doaj.org-article:b9c74857e4914428bf5c350db3854c462021-12-02T14:39:47ZControl of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen10.1038/s41467-017-02660-42041-1723https://doaj.org/article/b9c74857e4914428bf5c350db3854c462018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02660-4https://doaj.org/toc/2041-1723How pathogens maintain phenotypic robustness during infection is poorly understood. Here the authors couple the virulence regulatory network (VRN) of the pathogen R. solanacearum to a model of its metabolic network, and find that the VRN activates functionally redundant primary metabolism genes to promote phenotypic robustness during infection.Rémi PeyraudLudovic CottretLucas MarmiesseStéphane GeninNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rémi Peyraud Ludovic Cottret Lucas Marmiesse Stéphane Genin Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
description	How pathogens maintain phenotypic robustness during infection is poorly understood. Here the authors couple the virulence regulatory network (VRN) of the pathogen R. solanacearum to a model of its metabolic network, and find that the VRN activates functionally redundant primary metabolism genes to promote phenotypic robustness during infection.
format	article
author	Rémi Peyraud Ludovic Cottret Lucas Marmiesse Stéphane Genin
author_facet	Rémi Peyraud Ludovic Cottret Lucas Marmiesse Stéphane Genin
author_sort	Rémi Peyraud
title	Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
title_short	Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
title_full	Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
title_fullStr	Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
title_full_unstemmed	Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
title_sort	control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b9c74857e4914428bf5c350db3854c46
work_keys_str_mv	AT remipeyraud controlofprimarymetabolismbyavirulenceregulatorynetworkpromotesrobustnessinaplantpathogen AT ludoviccottret controlofprimarymetabolismbyavirulenceregulatorynetworkpromotesrobustnessinaplantpathogen AT lucasmarmiesse controlofprimarymetabolismbyavirulenceregulatorynetworkpromotesrobustnessinaplantpathogen AT stephanegenin controlofprimarymetabolismbyavirulenceregulatorynetworkpromotesrobustnessinaplantpathogen
_version_	1718390497858289664

Control of primary metabolism by a virulence regulatory network promotes robustness in a plant pathogen

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