Antimicrobial hydrogels: promising materials for medical application

Kerong Yang, Qing Han, Bingpeng Chen, Yuhao Zheng, Kesong Zhang, Qiang Li, Jincheng Wang Department of Orthopedics, The Second Hospital, Jilin University, Changchun, Jilin, People’s Republic of China Abstract: The rapid emergence of antibiotic resistance in pathogenic microbes is becomin...

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Autores principales:	Yang KR, Han Q, Chen B, Zheng Y, Zhang K, Li Q, Wang JC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	nanomaterials nanoparticles antibiotics drug delivery infection Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b9cb2e017bf74a009f9cd01bb97d69ea
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spelling	oai:doaj.org-article:b9cb2e017bf74a009f9cd01bb97d69ea2021-12-02T06:00:45ZAntimicrobial hydrogels: promising materials for medical application1178-2013https://doaj.org/article/b9cb2e017bf74a009f9cd01bb97d69ea2018-04-01T00:00:00Zhttps://www.dovepress.com/antimicrobial-hydrogels-promising-materials-for-medical-application-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Kerong Yang, Qing Han, Bingpeng Chen, Yuhao Zheng, Kesong Zhang, Qiang Li, Jincheng Wang Department of Orthopedics, The Second Hospital, Jilin University, Changchun, Jilin, People’s Republic of China Abstract: The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested. Keywords: nanomaterials, hydrogels, nanoparticles, antibiotics, drug delivery, infectionYang KRHan QChen BZheng YZhang KLi QWang JCDove Medical Pressarticlenanomaterialsnanoparticlesantibioticsdrug deliveryinfectionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2217-2263 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	nanomaterials nanoparticles antibiotics drug delivery infection Medicine (General) R5-920
spellingShingle	nanomaterials nanoparticles antibiotics drug delivery infection Medicine (General) R5-920 Yang KR Han Q Chen B Zheng Y Zhang K Li Q Wang JC Antimicrobial hydrogels: promising materials for medical application
description	Kerong Yang, Qing Han, Bingpeng Chen, Yuhao Zheng, Kesong Zhang, Qiang Li, Jincheng Wang Department of Orthopedics, The Second Hospital, Jilin University, Changchun, Jilin, People’s Republic of China Abstract: The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an imminent global public health problem. Local application of antibiotics might be a solution. In local application, materials need to act as the drug delivery system. The drug delivery system should be biodegradable and prolonged antibacterial effect should be provided to satisfy clinical demand. Hydrogel is a promising material for local antibacterial application. Hydrogel refers to a kind of biomaterial synthesized by a water-soluble natural polymer or a synthesized polymer, which turns into gel according to the change in different signals such as temperature, ionic strength, pH, ultraviolet exposure etc. Because of its high hydrophilicity, unique three-dimensional network, fine biocompatibility and cell adhesion, hydrogel is one of the suitable biomaterials for drug delivery in antimicrobial areas. In this review, studies from the past 5 years were reviewed, and several types of antimicrobial hydrogels according to different ingredients, different preparations, different antimicrobial mechanisms, different antimicrobial agents they contained and different applications, were summarized. The hydrogels loaded with metal nanoparticles as a potential method to solve antibiotic resistance were highlighted. Finally, future prospects of development and application of antimicrobial hydrogels are suggested. Keywords: nanomaterials, hydrogels, nanoparticles, antibiotics, drug delivery, infection
format	article
author	Yang KR Han Q Chen B Zheng Y Zhang K Li Q Wang JC
author_facet	Yang KR Han Q Chen B Zheng Y Zhang K Li Q Wang JC
author_sort	Yang KR
title	Antimicrobial hydrogels: promising materials for medical application
title_short	Antimicrobial hydrogels: promising materials for medical application
title_full	Antimicrobial hydrogels: promising materials for medical application
title_fullStr	Antimicrobial hydrogels: promising materials for medical application
title_full_unstemmed	Antimicrobial hydrogels: promising materials for medical application
title_sort	antimicrobial hydrogels: promising materials for medical application
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b9cb2e017bf74a009f9cd01bb97d69ea
work_keys_str_mv	AT yangkr antimicrobialhydrogelspromisingmaterialsformedicalapplication AT hanq antimicrobialhydrogelspromisingmaterialsformedicalapplication AT chenb antimicrobialhydrogelspromisingmaterialsformedicalapplication AT zhengy antimicrobialhydrogelspromisingmaterialsformedicalapplication AT zhangk antimicrobialhydrogelspromisingmaterialsformedicalapplication AT liq antimicrobialhydrogelspromisingmaterialsformedicalapplication AT wangjc antimicrobialhydrogelspromisingmaterialsformedicalapplication
_version_	1718400132119003136

Antimicrobial hydrogels: promising materials for medical application

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